Q8TYY9

PR
Gene name
glyS
Protein name
Glycine--tRNA ligase
Names
Glycyl-tRNA synthetase, GlyRS
Species
Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
KEGG Pathway
mka:MK0152
EC number
6.1.1.14: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

77-149 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8TYY9

Entry ID Method Resolution Chain Position Source
AF-Q8TYY9-F1 Predicted AlphaFoldDB

No variants for Q8TYY9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8TYY9

No associated diseases with Q8TYY9

4 regional properties for Q8TYY9

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 156 - 448 IPR002314
domain Anticodon-binding 467 - 555 IPR004154
domain Aminoacyl-tRNA synthetase, class II 4 - 459 IPR006195
domain Glycyl-tRNA synthetase-like core domain 9 - 336 IPR033731

Functions

Description
EC Number 6.1.1.14 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
glycine-tRNA ligase activity Catalysis of the reaction: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly).
protein dimerization activity The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.

1 GO annotations of biological process

Name Definition
glycyl-tRNA aminoacylation The process of coupling glycine to glycyl-tRNA, catalyzed by glycyl-tRNA synthetase. The glycyll-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a glycine-accepting tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTEDVYERIM EIARRRGFIL PAFRIYGGAR GFYDYGPLGA LLKRKIEEKW REYYVHKEGF
70 80 90 100 110 120
MEIEAPNLLI GEVFEASGHV EHFIDPMTHC SECGEFFRAD HLAEEELGVD AEGMSPEELE
130 140 150 160 170 180
DLIREHDLRC PECGGELAEV TEFNLMFDTN IGPKEGRTGY LRPETAQAIF IQFKDLYRWA
190 200 210 220 230 240
RQKLPFGVVQ IGRAYRNEIS PRQGVIRLRE FTQAEAEVFF DPEEKEYPGF ERYADEVLKF
250 260 270 280 290 300
YPIEEQRKEN GEMLEMSVRE AVEEGMVSQP IGYFLGLTKR MLNEMGVPNE AIRSRQHLPE
310 320 330 340 350 360
ERAHYASDCW DVEVKLERFG WVEVVGIADR TDYDLKKHSE HSGEDLRAFR ELEEPKIVYR
370 380 390 400 410 420
PEPVMKELGP RFKSDAPKIA EALRRITAES EDELKGGLTV EVDGKEVEVP PECYEIVKEK
430 440 450 460 470 480
VTGERFYPHV IEPSYGIDRI LYCVLEHNFD PEEGVFRFPA WLAPIEVGVF PLLKRSDMVE
490 500 510 520 530 540
YARRVARMLR EEGFTVEYDD SGSIGRRYAR ADEIGVPYCV TVDHETLEDD TVTIRDRDTT
550 560 570
EQVRVEVDEL ADVLRGLIDG DLEFEEAGDP V