Q8TYL4

PR
Gene name
pcm
Protein name
Protein-L-isoaspartate O-methyltransferase
Names
L-isoaspartyl protein carboxyl methyltransferase, Protein L-isoaspartyl methyltransferase, Protein-beta-aspartate methyltransferase, PIMT
Species
Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
KEGG Pathway
mka:MK0282
EC number
2.1.1.77: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-46 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8TYL4

Entry ID Method Resolution Chain Position Source
AF-Q8TYL4-F1 Predicted AlphaFoldDB

No variants for Q8TYL4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8TYL4

No associated diseases with Q8TYL4

No regional properties for Q8TYL4

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q8TYL4

Functions

Description
EC Number 2.1.1.77 Methyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

1 GO annotations of molecular function

Name Definition
protein-L-isoaspartate (D-aspartate) O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + protein L-beta-aspartate = S-adenosyl-L-homocysteine + protein L-beta-aspartate methyl ester.

1 GO annotations of biological process

Name Definition
protein repair The process of restoring a protein to its original state after damage by such things as oxidation or spontaneous decomposition of residues.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAEDDKVFRR ARERLVERLK SLGYIRSNRV AEAMLKVPRH EFVPEDLRDR AYVDSPLPIG
70 80 90 100 110 120
RGQTISAPHM VAIMTELLDP RPGHKVLEVG AGSGYHAAVV AELVKPDGRV ITVERIPELA
130 140 150 160 170 180
DFARNNLKKT GYDRFVKVLV GDGTKGYPPE APYDRILVTA GAPDVPESLL EQLKPGGKMV
190 200 210 220
IPVGDRHMQE LWLVEKTEDG EIRRRRHGGC AFVPLIGEEG FQEPES