Q8TY09

PR
Gene name
purL
Protein name
Phosphoribosylformylglycinamidine synthase subunit PurL
Names
FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit II, FGAR amidotransferase II, FGAR-AT II, Glutamine amidotransferase PurL, Phosphoribosylformylglycinamidine synthase subunit II
Species
Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
KEGG Pathway
mka:MK0497
EC number
6.3.5.3: Carbon--nitrogen ligases with glutamine as amido-N-donor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-41 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8TY09

Entry ID Method Resolution Chain Position Source
AF-Q8TY09-F1 Predicted AlphaFoldDB

No variants for Q8TY09

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8TY09

No associated diseases with Q8TY09

5 regional properties for Q8TY09

Type Name Position InterPro Accession
domain PurM-like, C-terminal domain 186 - 340 IPR010918-1
domain PurM-like, C-terminal domain 557 - 699 IPR010918-2
domain PurM-like, N-terminal domain 60 - 174 IPR016188-1
domain PurM-like, N-terminal domain 434 - 543 IPR016188-2
domain Phosphoribosylformylglycinamidine synthase, linker domain 2 - 37 IPR041609

Functions

Description
EC Number 6.3.5.3 Carbon--nitrogen ligases with glutamine as amido-N-donor
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
magnesium ion binding Binding to a magnesium (Mg) ion.
phosphoribosylformylglycinamidine synthase activity Catalysis of the reaction: N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + ATP + H(2)O = 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate + ADP + 2 H(+) + phosphate.

1 GO annotations of biological process

Name Definition
'de novo' IMP biosynthetic process The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTLDERDLEL IREELGRDPN ATERAMFENM WSEHCAYRST RHLLRQLPSE ADHVIVGPGD
70 80 90 100 110 120
DAAVVAIDDE WAVVVGIESH NHPSYVDPYN GAATGVGGIV RDVLSMGAFP IALLDPLRFG
130 140 150 160 170 180
PLDGERVPYL VDGVVRGISD YGNRIGVPTV GGELEFDPSY ERNPLVNVMC VGIVRRSEIV
190 200 210 220 230 240
RGRADRPGDV LVLVGARTGR DGIGGAAFAS EELGEESEEE DRPAVQIGDP FTERQLIIAI
250 260 270 280 290 300
REAVERGLVK GCKDLGAAGL TCAATEMAAD GGTGVEIDVF KVPLREEGME PWEIMLSESQ
310 320 330 340 350 360
ERMLLVVAPE DVDEVIEICR KYGLEASVVG RVTDDGYLTV KDGDDVIARV PAEFLADGAP
370 380 390 400 410 420
EVEWEEEPYS YPENVDVPEP DPEDLVRSVL SSPNVSPALR EWVYRQYDHE VQGRTVVKPG
430 440 450 460 470 480
HDAAVMWLQH EGLEDVALAL TTDSNPRHVL IDPKTGTEGC VAEALRNLAT VGAEPLCLVD
490 500 510 520 530 540
CLNFGSPENP RVYYQLRRSI EGLGKAAREF EVPVVGGNVS LYNEHEVDGP VNPTPVIGAV
550 560 570 580 590 600
GVIRGLDYLE DFPREPEEGE AVIVLGETRE ELGGSLYLIE YHGIKGGKVP RVRYREERAL
610 620 630 640 650 660
HDLLRRIARK NMVSSVTDVS TGGLLAAVAE LLGPVGASLS LSEVPNSVSR WDFLLLSESH
670 680 690 700 710 720
GRAIVTTDRP DDVLGAAEEA GVPAQVVGEV TGDGVLRISV GPVDVSLDRE ELEELWRSPL
HYLE