Q8TXJ7

PR
Gene name
truD
Protein name
Probable tRNA pseudouridine synthase D
Names
tRNA pseudouridine(13) synthase, tRNA pseudouridylate synthase D, tRNA-uridine isomerase D
Species
Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
KEGG Pathway
mka:MK0676
EC number
5.4.99.27: Transferring other groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-127 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8TXJ7

Entry ID Method Resolution Chain Position Source
AF-Q8TXJ7-F1 Predicted AlphaFoldDB

No variants for Q8TXJ7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8TXJ7

No associated diseases with Q8TXJ7

2 regional properties for Q8TXJ7

Type Name Position InterPro Accession
domain Pseudouridine synthase, TruD, insertion domain 158 - 379 IPR011760
conserved_site Pseudouridine synthase TruD, conserved site 80 - 93 IPR020119

Functions

Description
EC Number 5.4.99.27 Transferring other groups
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
RNA binding Binding to an RNA molecule or a portion thereof.
tRNA pseudouridine synthase activity Catalysis of the reaction: tRNA uridine = tRNA pseudouridine. Conversion of uridine in a tRNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5.

1 GO annotations of biological process

Name Definition
tRNA pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine in a tRNA molecule.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEKPSRNTYI PLTIVGECPE CREYHRGREC PECGQDLRRP RLRPQFGGRG PHTLFYLEKY
70 80 90 100 110 120
DWDTMKAVRR IAQALRKHHR HFGIAGMKDK RAVTSQRVTV RGVPPGVLAR LRIRDLKIVP
130 140 150 160 170 180
MGRARRKLRP GDLWGNRFVI TVRGAKVRRL PEALRTVREL GGVPNYYGLQ RFGSRRPVTH
190 200 210 220 230 240
VVGKYVVLED WEKAVKTFLT LEYPRESPEA LEARRWLKEH WGEFKEALRR FPKFLDYERH
250 260 270 280 290 300
ILEHLARHPH DYINAFRRLP MWIRRMFVHA YQSYLFNRIL SERIARGLPV HRPVEGDVTQ
310 320 330 340 350 360
DGLPTVPLPG FRTELSDGPQ GEIEREVLEE EGVRLEDFEI KSMPELSAGG DRKPALLRVY
370 380 390
GLRAEAIGDD TVRFTFSLPR GGYATTVLRE LLGSEGVYAD