Q8TX03
Gene name |
pan |
Protein name |
Proteasome-activating nucleotidase |
Names |
PAN, Proteasomal ATPase, Proteasome regulatory ATPase, Proteasome regulatory particle |
Species |
Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938) |
KEGG Pathway |
mka:MK0878 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8TX03
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8TX03-F1 | Predicted | AlphaFoldDB |
No variants for Q8TX03
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q8TX03 | |||||
No associated diseases with Q8TX03
5 regional properties for Q8TX03
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | AAA+ ATPase domain | 212 - 351 | IPR003593 |
| domain | ATPase, AAA-type, core | 216 - 349 | IPR003959 |
| conserved_site | ATPase, AAA-type, conserved site | 319 - 337 | IPR003960 |
| domain | Proteasomal ATPase OB C-terminal domain | 103 - 158 | IPR032501 |
| domain | AAA ATPase, AAA+ lid domain | 371 - 414 | IPR041569 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| proteasome-activating nucleotidase complex | A homohexameric complex that recognizes and unfolds core proteasome substrate proteins, and translocates them to the core complex in an ATP dependent manner. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| proteasome-activating activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate, which promotes unfolding of protein substrates, and channel opening of the core proteasome. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| proteasomal protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome. |
| protein unfolding | The process of assisting in the disassembly of non-covalent linkages in a protein or protein aggregate, often where the proteins are in a non-functional or denatured state. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEETGVKDVR | DLCEKFLDFK | REKERLEELL | KEYFKRLEEL | ERKLRAHEEK | LRIEARRRKT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LEKELEMERD | EKAELREELR | RKEVMIEKLR | SDLQRMKKPP | LIVGTVEEIL | DDGRVIVKSS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TGPKFVSNVS | PTVDRNELEP | GANVALNQQS | MAVVDVLPSE | KDSRVLAMEV | DESPDVSYDD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IGGLDEQIRE | IREVVEKPLK | EPELFEKVGV | EPPKGVLLYG | PPGTGKTLLA | KAVANHADAT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FIRLAAPELV | QKFIGEGARL | VRELFELARE | KAPSIIFIDE | IDAIGARRMR | DATSGDREVQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RTLTQLLAEM | DGFDPLDDIK | VIAATNRKDI | LDPALLRPGR | FDRHIKIPLP | DEEGRYEIFK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| IHTRDMNLAE | DVDLQKLAKI | TEGASGADIK | AICTEAGMMA | IREDRDIVTM | DDFLKAVDRV |
| 430 | |||||
| MGKKEEESGE | FKRAYH |