Q8TUV3
Gene name |
polC |
Protein name |
DNA polymerase II large subunit |
Names |
Pol II, Exodeoxyribonuclease large subunit |
Species |
Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938) |
KEGG Pathway |
mka:MK1650 |
EC number |
2.7.7.7: Nucleotidyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8TUV3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8TUV3-F1 | Predicted | AlphaFoldDB |
No variants for Q8TUV3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q8TUV3 | |||||
No associated diseases with Q8TUV3
2 regional properties for Q8TUV3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | DNA polymerase II large subunit DP2, N-terminal | 10 - 139 | IPR016033-1 |
| domain | DNA polymerase II large subunit DP2, N-terminal | 165 - 988 | IPR016033-2 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.7.7 | Nucleotidyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| 3'-5' exonuclease activity | Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. |
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| DNA-directed DNA polymerase activity | Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group. |
| exodeoxyribonuclease I activity | Catalysis of the degradation of single-stranded DNA. It acts progressively in a 3' to 5' direction, releasing 5'-phosphomononucleotides. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA catabolic process, exonucleolytic | The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of terminal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides. |
| DNA-templated DNA replication | A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNRAREELDR | YRETLEEVSS | RFVDVATKAR | QRREDPKPEP | EVMLATSIGE | RVEGLLQVEN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VADRLEELEE | ELGDREEATF | RIVEEVIKGE | LKVKGDLPLH | KRIDYAVRIG | LAVLTEAVVS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| APLEGIAAVE | IRERGTGHRV | VDESEPPHEE | PKLVCTECGK | EVDPENCYLA | VKYAGPIRAA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GGTAAALSAL | LADYARQVAG | LPRFNPDDFD | HDLVGRYVEE | VVTYLDKVGS | FQYNPSEEEV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ELVAKNIPIE | IDGEPTEEVE | VQGHRDIPHL | PNQLRGGALL | VICEGICQKA | PKLIKRVEKY |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GIDGWEFLEK | LVNKGSDDEE | EGEEEKTKIK | PNDKYMGELV | AGRPLLSHPS | AKGGFRLRYG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RARNTGFAAV | GVHPSLMYVT | KGFIVIGTQL | KVERPGKAAC | VLPVTEIEPP | VVKLRDGSVV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| RLDDPREAKE | LVEKDEIEEI | LDLGEMLVAV | GEFIENNHPL | VPPAYCPEWW | VKEVPDVVKV |
| 490 | 500 | 510 | 520 | 530 | 540 |
| IGLRKNLPND | VFEKLKDVPL | KRLVKEASRL | SGNGNNLDGF | LNGPVKVARS | IVELVRKEVI |
| 550 | 560 | 570 | 580 | 590 | 600 |
| PRLSSPERMS | VEEAIELSRE | YGVPFHPKYT | FLWHDVKPKD | VDELREALEV | AGSEWGNLRV |
| 610 | 620 | 630 | 640 | 650 | 660 |
| EFENDGEIKR | ILEDLLVPHR | LEDDTIVVEE | PWASALLAQL | GYDPESGEFR | EQDEDLDYLL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| DYLVIRDETC | RYVSKLAGFP | IREKAPTRIG | ARMGRPEKAR | ERKMSPPPHV | LFPIGIAGGN |
| 730 | 740 | 750 | 760 | 770 | 780 |
| QRDIMKFHRG | ESEDTDRVEV | CYRICPECDR | LVPYRVCPFC | GTETVQYCNR | CDEPADECDC |
| 790 | 800 | 810 | 820 | 830 | 840 |
| EEPDPVVRAD | IERNDDPYSS | LPVRELVRRA | EEEVGTTDTL | KGVKGMTSRL | KMPEPLQKGI |
| 850 | 860 | 870 | 880 | 890 | 900 |
| LRAKRDLFVF | KDGTLRFDCN | DCPLTHVRLK | EVGLTPFKAR | LLGFERDING | DPVVSEDQVV |
| 910 | 920 | 930 | 940 | 950 | 960 |
| ELYPQDVVLP | RKAAEWAVRV | CQYLDDLLRK | YYGLEPVYGV | EKPEDLIGHL | IVTLAPHTSC |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| GVVGRVVGIA | DINCWYNHPI | INAARRRNCD | GDEDAFMLLL | DVLLNFSRLY | LPDKRGGLMD |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| APLVLTAVVD | PYEIDDEVWN | MDVCGDYPLE | LYRKALEYAD | AGEAEELIER | LEDRLDLPRG |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| LQFTHDTEAI | DLGPTVTRYS | RLEKMEEKLE | EQLDLARRIR | AVDESDVAKI | VLDSHFLPDI |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| KGNLRKFGRQ | KFRCSRCNAK | FNVPPLSGKC | PRCGGDVLLT | IYPATATKYL | EPAKRLVEEF |
| 1210 | 1220 | 1230 | |||
| GTHDEEWRTI | ASEVELLEEE | AKTLFGSDHS | VSLKKFFGET |