Q8TK89
Gene name |
tiaS |
Protein name |
tRNA(Ile2) 2-agmatinylcytidine synthetase TiaS |
Names |
tRNA(Ile2)-agm2C synthetase, tRNA(Ile2) agmatidine synthetase |
Species |
Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) |
KEGG Pathway |
mac:MA_3525 |
EC number |
6.3.4.22: Other carbon--nitrogen ligases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8TK89
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8TK89-F1 | Predicted | AlphaFoldDB |
No variants for Q8TK89
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q8TK89 | |||||
No associated diseases with Q8TK89
1 regional properties for Q8TK89
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Domain of unknown function DUF1743 | 140 - 256 | IPR013696 |
Functions
| Description | ||
|---|---|---|
| EC Number | 6.3.4.22 | Other carbon--nitrogen ligases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ligase activity, forming carbon-nitrogen bonds | Catalysis of the joining of two molecules, or two groups within a single molecule, via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| tRNA wobble cytosine modification | The process in which a cytosine in position 34 of a tRNA is post-transcriptionally modified. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MIIGIDDTDS | NEGMCTTYLG | ALLLEELQEY | GTVETLPLLV | RLNPTIPYKT | RGNAAIALKL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KTDCPEKIIA | HVTSRIEEFA | RMECEKTNPG | AVFIQEKDYR | SLKPILLSFL | EKAVKDVIEI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ETAKHLISEL | GISSKSFKNG | RGLIGALAAC | GAMLNPEKWD | CTFEHLAYRQ | KKKWGSPRDV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NKDSFFEADR | QTYPGTWDTV | DLANRLVVCV | PHSADPVLFG | IRGESPELVS | KAASLIRSEP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VERFAVYRTN | QGTDMHLLPA | ASISEIRDMH | SYRFEGTVSA | VPKTIEGGHV | IFAVRDGKGD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EIDCAAFEPT | KNFRVLARRL | LLGDQIFLSG | SVTSGTLNIE | KMQVKELVLL | YREENPKCPE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| CGKHMKSAGQ | GQGFRCKKCG | TRASSKIRCE | AERDLEPGLY | EVPPCARRHL | AKPLARERDQ |
| NIRIHPSR |