Q8TII9

PR
Gene name
atpD
Protein name
V-type ATP synthase subunit D
Names
V-ATPase subunit D
Species
Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
KEGG Pathway
mac:MA_4160
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-52 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8TII9

Entry ID Method Resolution Chain Position Source
AF-Q8TII9-F1 Predicted AlphaFoldDB

No variants for Q8TII9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8TII9

No associated diseases with Q8TII9

No regional properties for Q8TII9

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q8TII9

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
proton-transporting V-type ATPase complex A proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across a concentration gradient. The resulting transmembrane electrochemical potential of H+ is used to drive a variety of (i) secondary active transport systems via H+-dependent symporters and antiporters and (ii) channel-mediated transport systems. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis. V-type ATPases are found in the membranes of organelles such as vacuoles, endosomes, and lysosomes, and in the plasma membrane.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
proton-transporting ATP synthase activity, rotational mechanism Enables the synthesis of ATP from ADP and phosphate by the transfer of protons from one side of a membrane to the other by a rotational mechanism driven by a gradient according to the reaction: ADP + H2O + phosphate + H+(in) -> ATP + H+(out).
proton-transporting ATPase activity, rotational mechanism Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism.

1 GO annotations of biological process

Name Definition
proton motive force-driven plasma membrane ATP synthesis The transport of protons across the plasma membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAQQDVKPTR SELINLKKKI KLSESGHKLL KMKRDGLILE FFKILNEARN VRTELDAAYE
70 80 90 100 110 120
KSTEKINLAS AVNGMVAVKS TAFTAKEYPE IQLSGHNIMG VVVPKISSTG VRKPLYERGY
130 140 150 160 170 180
GIIGTNSYID ETADAYEELV EKIIAAAELE TTMKRLLDEI EKTKRRVNAL EFKVIPELIA
190 200
TMKYIRFMLE EMERENTFRL KRVKARMKN