Q8TIB9

PR
Gene name
hdrC2
Protein name
Ferredoxin/F(420)H(2)-dependent CoB-CoM heterodisulfide reductase subunit C
Names
Coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase subunit C, Ferredoxin:CoB-CoM heterodisulfide reductase subunit C
Species
Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
KEGG Pathway
mac:MA_4236
EC number
1.8.7.3: With an iron-sulfur protein as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

87-161 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8TIB9

Entry ID Method Resolution Chain Position Source
AF-Q8TIB9-F1 Predicted AlphaFoldDB

No variants for Q8TIB9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8TIB9

No associated diseases with Q8TIB9

2 regional properties for Q8TIB9

Type Name Position InterPro Accession
domain 4Fe-4S ferredoxin-type, iron-sulphur binding domain 10 - 82 IPR017896
conserved_site 4Fe-4S ferredoxin, iron-sulphur binding, conserved site 62 - 73 IPR017900

Functions

Description
EC Number 1.8.7.3 With an iron-sulfur protein as acceptor
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
4 iron, 4 sulfur cluster binding Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
CoB--CoM heterodisulfide reductase activity Catalysis of the reaction: coenzyme B + coenzyme M + methanophenazine = N-{7-[(2-sulfoethyl)dithio]heptanoyl}-3-O-phospho-L-threonine + dihydromethanophenazine.
metal ion binding Binding to a metal ion.

1 GO annotations of biological process

Name Definition
methanogenesis The chemical reactions and pathways resulting in the formation of methane, a colorless, odorless, flammable gas with the formula CH4. It is the simplest of the alkanes.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSEELLKLLK AEGLDLLSCM HCGICTGSCP SGRHTGLNTR RIIRDARKNR AAVLSDYDLW
70 80 90 100 110 120
LCTTCYTCQE RCPRGIPITD AILELRRLAV REGLMLPEHR FVSEMVLECG HAVPLDEETK
130 140 150 160
KKREELGLDP IPETVQKDPE ALEGLKTLLK TCKFDELVAK K