Q8TH08
Gene name |
tgtA |
Protein name |
tRNA-guanine(15) transglycosylase |
Names |
7-cyano-7-deazaguanine tRNA-ribosyltransferase, Archaeal tRNA-guanine transglycosylase |
Species |
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) |
KEGG Pathway |
pfu:PF1046 |
EC number |
2.4.2.48: Pentosyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8TH08
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8TH08-F1 | Predicted | AlphaFoldDB |
No variants for Q8TH08
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q8TH08 | |||||
No associated diseases with Q8TH08
5 regional properties for Q8TH08
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | PUA domain | 508 - 582 | IPR002478 |
| domain | tRNA-guanine(15) transglycosylase-like | 10 - 341 | IPR002616 |
| domain | Uncharacterised domain CHP00451 | 490 - 578 | IPR004521 |
| domain | tRNA-guanine transglycosylase, patch-forming domain C2 | 440 - 506 | IPR029402 |
| domain | tRNA-guanine(15) transglycosylase, C1 domain | 361 - 430 | IPR032729 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.4.2.48 | Pentosyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| metal ion binding | Binding to a metal ion. |
| pentosyltransferase activity | Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor). |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| tRNA modification | The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSRGDSMLRF | EIKDRDAAGR | IGKLEVNGKK | IETPAIMPVV | NPKQLIVEPK | ELKRMGFDII |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ITNSYIIYKD | KKLREKALEK | GIHRLLDYDG | IIEVDSGSFQ | LMRYGKVEVT | NREIVEFQHK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IGVDIGTFLD | IPTPPDAPRE | KAEQDLKITL | ERAKEAESIK | QIPMNATVQG | STYLDLRKLA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ARKLSEMNFE | IHPIGAVVPL | LESYRFKDVV | DIVIASKMGL | RPDRPVHLFG | AGHPMVFALA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VAMGVDLFDS | ASYALYAKDD | RYLTPQGTKR | LEELEYFSCS | CPVCSKYTPQ | ELREMPKEER |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EKLLALHNLW | VIREEINRVK | QAIKEGELWR | LVDERARAHP | KLYAAYKRLL | EYYHYLEEYE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PITKKSAFFK | ISEESLKWPI | ARRAKERAEK | VKAKFPESIP | HPIFGEIPKY | LSLTYPFAQS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ESEEDFQIEK | PTRENAILYI | MAIAEYQFGE | GAGEAFRDAE | VEIAKTGMPR | QVKKNGKRLA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| TVRAEDGLLT | LGIEGAKRLH | ELLPYPVMRV | VVNKEAEPFA | RKGKDVFAKF | VEFADPKIRP |
| 550 | 560 | 570 | 580 | ||
| YDEVLIVNEN | DELLATGQAL | LSGREMVLFS | SGRAVKTRRG | VEEKK |