Q8TGX2
Gene name |
cca |
Protein name |
CCA-adding enzyme |
Names |
CCA tRNA nucleotidyltransferase, tRNA CCA-pyrophosphorylase, tRNA adenylyl-/cytidylyl- transferase, tRNA nucleotidyltransferase, tRNA-NT |
Species |
Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) |
KEGG Pathway |
mac:MA_3559 |
EC number |
2.7.7.72: Nucleotidyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8TGX2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8TGX2-F1 | Predicted | AlphaFoldDB |
No variants for Q8TGX2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q8TGX2 | |||||
No associated diseases with Q8TGX2
No regional properties for Q8TGX2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q8TGX2 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.7.72 | Nucleotidyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
7 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity | Catalysis of the reaction: a tRNA with a 3' CC end + ATP = a tRNA with a 3' CCA end + diphosphate. |
| CTP:3'-cytidine-tRNA cytidylyltransferase activity | Catalysis of the reaction: a tRNA with a 3' cytidine + CTP = a tRNA with a 3' CC end + diphosphate. |
| CTP:tRNA cytidylyltransferase activity | Catalysis of the reaction: a tRNA precursor + CTP = a tRNA with a 3' cytidine end + diphosphate. |
| magnesium ion binding | Binding to a magnesium (Mg) ion. |
| tRNA binding | Binding to a transfer RNA. |
| tRNA cytidylyltransferase activity | Catalysis of the reaction: CTP + tRNA(n) = diphosphate + tRNA(n+1). |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| RNA repair | Any process that results in the repair of damaged RNA. |
| tRNA 3'-terminal CCA addition | Post-transcriptional addition of the terminal 3' CCA sequence to a tRNA which does not encode this sequence within the primary transcript. CCA addition proceeds by the sequential addition of CTP, CTP, and then ATP to the 3' end of the tRNA, yielding a diphosphate with each nucleotide addition. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEKDTSIPED | LKLAVLEKIK | PTEAERKILT | AVQEELAAEV | KAAAEKLCVA | DIFVKMVGSA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ARGTWLSGTH | DIDVFISFPE | ETSREELERR | GMEIAREVAK | KAEHAEDRHA | EHPYLNIVFK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GFDVDLVPCF | RVESACQLKS | AVDRTPFHNE | FVKTHIKGRE | DDVLLMKQFM | RGGGVYGSEL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KTQGFSGYLT | ELLIIHYGSF | ENTVKAACLW | KPGKKIDIMQ | HSEMEHTEPL | VMVDPTDPKR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NVAAALSLDK | FCMFMDHCRE | FMKSPGLNFF | FPPPLSPLED | REFLEKLESR | KSSQLAIVFK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TPDIVDDVLY | PQLYKMEQAA | AALLHEYDFS | VIKTGVWSGK | PETVVMLELI | SGTLPNVKKR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| IGPPVWVREH | AEKFKAKYEG | AENVFGGYIE | GGKYVFEIQR | KYPTAKGLLE | NQLLNCSLGK |
| 430 | 440 | 450 | |||
| QVKSSVSAGF | EVIEDAEICR | LKDPDFRVFL | RKWV |