Q8TG24

PR
Gene name
MET3
Protein name
Sulfate adenylyltransferase
Names
ATP-sulfurylase, Sulfate adenylate transferase, SAT
Species
Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii)
KEGG Pathway
EC number
2.7.7.4: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

317-429 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8TG24

Entry ID Method Resolution Chain Position Source
AF-Q8TG24-F1 Predicted AlphaFoldDB

No variants for Q8TG24

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8TG24

No associated diseases with Q8TG24

2 regional properties for Q8TG24

Type Name Position InterPro Accession
domain Sulphate adenylyltransferase catalytic domain 181 - 394 IPR024951
domain ATP-sulfurylase PUA-like domain 4 - 171 IPR025980

Functions

Description
EC Number 2.7.7.4 Nucleotidyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
adenylylsulfate kinase activity Catalysis of the reaction: ATP + adenylylsulfate = ADP + 3'-phosphoadenosine 5'-phosphosulfate.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
sulfate adenylyltransferase (ATP) activity Catalysis of the reaction: ATP + sulfate = diphosphate + adenylylsulfate.

4 GO annotations of biological process

Name Definition
cysteine biosynthetic process The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid.
hydrogen sulfide biosynthetic process The chemical reactions and pathways resulting in the formation of hydrogen sulfide, H2S.
methionine biosynthetic process The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.
sulfate assimilation The pathways by which inorganic sulfate is processed and incorporated into sulfated compounds.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MANAPHGGVL KDLLVRDAAL HDSLLEEARS LNDIFLTERQ LCDLELILNG GFSPLEGFMD
70 80 90 100 110 120
EQDYTSVVET LRLAPFNGHK YGHVFPIPIT LDVSQEDINT LGLKQGARVA LRDPRDDAAL
130 140 150 160 170 180
AILTVSDIYR PNKATEAEKV MGADDIAHPS VAYLRNNVKE FYVGGKVQAI QAPTHFDYVP
190 200 210 220 230 240
LRYTPAELRA HFHKLAWRKV VAFQTRNPMH RAHRELTVRA ARQRRANVLI HPVVGLTKPG
250 260 270 280 290 300
DVDHYTRVRA YQALMPSYPE GMAHLALLPL AMRMAGPREA VWHAVIRKNF GATHFIVGRD
310 320 330 340 350 360
HAGPGKNSQG KDFYGPYDAQ ELVTQFKDEL QIEMVPFQAM TYLPGSDEYQ PVDEVPKGTP
370 380 390 400 410 420
TADISGTELR KRLRTGASIP DWFSYTGVVK VLRESYPPRP QQGFTILLTG LHNSGKDTIA
430 440 450 460 470 480
RALQVTLQQQ GSRSVSLLLG EELRSDLDPQ IGRAITPEQK HINLERIGFV AAELTKAGAA
490 500 510 520 530 540
VIAAPTAPYE RSRQAFKKQV VGSGGGNYFL VHVATPLEWC EKVDRRGLYK AARAGEIKNL
550 560 570 580
TGVDDVYEAP ENADLVCDLR IDTVPEIVHS IIMILESQNL V