Q8TFH7
Gene name |
sen2 (SPAPB17E12.07c) |
Protein name |
Probable tRNA-splicing endonuclease subunit sen2 |
Names |
tRNA-intron endonuclease sen2 |
Species |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
KEGG Pathway |
spo:SPAPB17E12.07c |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8TFH7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8TFH7-F1 | Predicted | AlphaFoldDB |
5 variants for Q8TFH7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| I_1278865_C_T | 37 | R>Q | No | Jeffares_SNPs | |
| I_1278638_C_T | 113 | A>T | No | Jeffares_SNPs | |
| I_1278469_C_T | 169 | R>Q | No | Jeffares_SNPs | |
| I_1277912_T_C | 339 | D>G | No | Jeffares_SNPs | |
| I_1277831_C_T | 366 | R>Q | No | Jeffares_SNPs |
No associated diseases with Q8TFH7
1 regional properties for Q8TFH7
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | tRNA intron endonuclease, catalytic domain-like | 250 - 333 | IPR006677 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| mitochondrial outer membrane | The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. |
| tRNA-intron endonuclease complex | A protein complex that catalyzes the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| lyase activity | Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. |
| nucleic acid binding | Binding to a nucleic acid. |
| tRNA-intron endonuclease activity | Catalysis of the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| tRNA-type intron splice site recognition and cleavage | RNA processing that begins when the tertiary structure of a tRNA type intron is recognized, and ends when the endonucleolytic cleavage of the RNA at both the 5' and 3' splice sites occurs. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSKNHEVYKD | ALPISLAYPL | PPIILTNPLT | WIPYIYRYLF | RKTPRQVQWQ | CQLHESDLSC |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VVTDSEAIKK | FWTSGFFGKG | NLSRSEPTWH | TRTKRSLGLL | GFDEDLVAEE | VTARRRFQRK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QFKAQRAYRE | NRARERQLLL | ENGKPIPASL | EEDAELPEYL | TKSLKDFSRV | SENPYHITSV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PNVEHLQLTF | PEAFFLASLG | VLRINYENPN | FELLPILKLF | ANIVANSVAL | THDYSLQQSH |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EDPIIEPDNK | FLTELAAYFY | FRQQGWVVKN | GTKFSVDFLL | YKKGPVFSHA | EFAILLIPCV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GNKQKYNMQW | HEVHCLNRVI | AQVKKSLILC | YVQCPSIEDF | NKIWKNQASM | NEWDWAESVL |
| 370 | |||||
| RQYLIRCVTL | RRWVPSRNRD |