Q8TFH4
Gene name |
SPAPB17E12.10c |
Protein name |
Putative ribosomal RNA methyltransferase PB17E12.10c |
Names |
rRNA (uridine-2'-O-)-methyltransferase |
Species |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
KEGG Pathway |
spo:SPAPB17E12.10c |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8TFH4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8TFH4-F1 | Predicted | AlphaFoldDB |
2 variants for Q8TFH4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| I_1282498_T_C | 13 | Y>C | No | Jeffares_SNPs | |
| I_1282149_G_T | 72 | L>I | No | Jeffares_SNPs |
No associated diseases with Q8TFH4
1 regional properties for Q8TFH4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Ribosomal RNA methyltransferase, FtsJ domain | 64 - 271 | IPR002877 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| RNA methyltransferase activity | Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. |
| rRNA (uridine-2'-O-)-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methyluridine. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| mitochondrial RNA metabolic process | The chemical reactions and pathways involving RNA transcribed from the mitochondrial genome and occurring in the mitochondrion. |
| RNA methylation | Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSMRIWSRSS | SAYSAIARSS | SWFNNSLFSS | CLLRFYSNPP | KKTKKNTLIS | LRKSAETANE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KFIEKINKEH | QLFKPGQIVV | DLGCAPGIWS | TIAARHVGLF | GRVIACDIIP | CRLPENSSMI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QGNILSMEIQ | LEIAKAAIRS | RNSFFRNQQD | HNSASIPYLQ | SVFEEERDTK | EKAKIEDLSA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DVIMSDLGPP | FPMVQGFEFW | ISKLPYLAMQ | TNEHLAVKDE | LDSLYLAQAA | LLFAIKALKP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DGIFLCKVLE | SSHLRSFAED | LSMCFKCVKK | IQFKTKIKDE | LYAVYFCSGK | QLSCHSKLLN |
| I |