Q8TBZ2
Gene name |
MYCBPAP |
Protein name |
MYCBP-associated protein |
Names |
AMAM-1, AMY-1-binding protein 1, AMAP-1 |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:84073 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8TBZ2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8TBZ2-F1 | Predicted | AlphaFoldDB |
3 variants for Q8TBZ2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
rs1380657 VAR_035003 CA8649610 |
387 | A>T | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
CA8649873 rs9890721 VAR_035004 |
688 | R>W | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
CA8650081 VAR_035005 rs1133818 |
910 | S>R | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
No associated diseases with Q8TBZ2
No regional properties for Q8TBZ2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q8TBZ2 | |||
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| synapse | The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cell differentiation | The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| chemical synaptic transmission | The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. |
| spermatogenesis | The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8IYW4 | ENTHD1 | ENTH domain-containing protein 1 | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVPGGTMKSL | KKDSRLRITP | TRLLEASENV | KEKKRAKGPE | QPTPTIQEEP | EPVSNVLQGD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DILALAIKKE | DLKEQHIPRL | TEKEDKRVIT | QKFIIRKLKP | MDPRRKVCHL | VARPANPDEA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TKPLDYSGPG | DSFDGSDQIL | PHHILGSLQD | FKRIALARGN | TQLAERIPTS | PCLMTLISAE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GESKQKAPKE | EKRPPWAPPP | QHNFLKNWQR | NTALRKKQQE | ALSEHLKKPV | SELLMHTGET |
| 250 | 260 | 270 | 280 | 290 | 300 |
| YRRIQEEREL | IDCTLPTRRD | RKSWENSGFW | SRLEYLGDEM | TGLVMTKTKT | QRGLMEPITH |
| 310 | 320 | 330 | 340 | 350 | 360 |
| IRKPHSIRVE | TGLPAQRDAS | YRYTWDRSLF | LIYRRKELQR | IMEELDFSQQ | DIDGLEVVGK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GWPFSAVTVE | DYTVFERSQG | SSSEDTAYLG | TLASSSDVSM | PILGPSLLFC | GKPACWIRGS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| NPQDKRQVGI | AAHLTFETLE | GEKTSSELTV | VNNGTVAIWY | DWRRQHQPDT | FQDLKKNRMQ |
| 490 | 500 | 510 | 520 | 530 | 540 |
| RFYFDNREGV | ILPGEIKTFT | FFFKSLTAGV | FREFWEFRTH | PTLLGGAILQ | VNLHAVSLTQ |
| 550 | 560 | 570 | 580 | 590 | 600 |
| DVFEDERKVL | ESKLTAHEAV | TVVREVLQEL | LMGVLTPERT | PSPVDAYLTE | EDLFRHRNPP |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LHYEHQVVQS | LHQLWRQYMT | LPAKAEEARP | GDKEHVSPIA | TEKASVNAEL | LPRFRSPISE |
| 670 | 680 | 690 | 700 | 710 | 720 |
| TQVPRPENEA | LRESGSQKAR | VGTKSPQRKS | IMEEILVEES | PDVDSTKSPW | EPDGLPLLEW |
| 730 | 740 | 750 | 760 | 770 | 780 |
| NLCLEDFRKA | VMVLPDENHR | EDALMRLNKA | ALELCQKPRP | LQSNLLHQMC | LQLWRDVIDS |
| 790 | 800 | 810 | 820 | 830 | 840 |
| LVGHSMWLRS | VLGLPEKETI | YLNVPEEQDQ | KSPPIMEVKV | PVGKAGKEER | KGAAQEKKQL |
| 850 | 860 | 870 | 880 | 890 | 900 |
| GIKDKEDKKG | AKLLGKEDRP | NSKKHKAKDD | KKVIKSASQD | RFSLEDPTPD | IILSSQEPID |
| 910 | 920 | 930 | 940 | ||
| PLVMGKYTQS | LHSEVRGLLD | TLVTDLMVLA | DELSPIKNVE | EALRLCR |