AiPD: Autoinhibited Protein Database

Q8TBB0

Gene name	THAP6
Protein name	THAP domain-containing protein 6
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:152815
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

141-212 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

141-212 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q8TBB0

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8TBB0-F1	Predicted				AlphaFoldDB

182 variants for Q8TBB0

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1365106903 CA357275833	2	V>M		No	ClinGen gnomAD
TCGA novel	4	C>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	5	C>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs140233330 CA99780099	5	C>W		No	ClinGen ESP
CA99780098 rs537952691	5	C>Y		No	ClinGen Ensembl
CA2964630 rs746616242	7	A>T		No	ClinGen ExAC TOPMed gnomAD
rs756898771 CA2964631	8	I>V		No	ClinGen ExAC gnomAD
CA357275878 rs1402428907	9	G>R		No	ClinGen gnomAD
rs780729665 CA2964632	10	C>R		No	ClinGen ExAC gnomAD
CA2964633 rs745427006	10	C>Y		No	ClinGen ExAC gnomAD
CA2964634 rs542042267	12	S>A		No	ClinGen 1000Genomes ExAC gnomAD
rs1240791873 CA357275903	13	R>C		No	ClinGen gnomAD
CA2964635 rs779910070	13	R>H		No	ClinGen ExAC TOPMed gnomAD
COSM1057545 CA357275939 rs1406454375	18	S>L	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
TCGA novel	19	K>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	20	L>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1256624696 CA357275967	22	G>E		No	ClinGen gnomAD
rs1463624026 CA357275976	24	T>A		No	ClinGen TOPMed
CA357275980 rs1201947856	24	T>I		No	ClinGen gnomAD
CA357275998 rs771120306	27	V>I		No	ClinGen ExAC TOPMed gnomAD
rs771120306 CA2964640	27	V>L		No	ClinGen ExAC TOPMed gnomAD
CA2964659 rs759822540	29	P>S		No	ClinGen ExAC gnomAD
rs769951434 CA2964661	36	R>K		No	ClinGen ExAC gnomAD
rs775749395 CA2964662	36	R>S		No	ClinGen ExAC gnomAD
CA2964664 rs764754857	38	W>*		No	ClinGen ExAC TOPMed gnomAD
rs912021529 CA357276265	38	W>G		No	ClinGen TOPMed gnomAD
CA99781165 rs912021529	38	W>R		No	ClinGen TOPMed gnomAD
rs1403160975 CA357276280	39	V>I		No	ClinGen gnomAD
rs751948588 CA2964665 COSM1540833	41	A>T	lung [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA357276307 rs1560540109	41	A>V		No	ClinGen Ensembl
rs1019822489 CA99781205	42	M>K		No	ClinGen Ensembl
rs1216494773 CA357276331	43	K>R		No	ClinGen gnomAD
rs750004487 CA2964668	46	D>E		No	ClinGen ExAC gnomAD
TCGA novel	46	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1294570286 CA357276387	48	N>D		No	ClinGen TOPMed gnomAD
rs201627689 CA2964671	48	N>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs754908166 CA2964672	49	A>V		No	ClinGen ExAC gnomAD
rs34942800 CA2964676	51	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs34942800 CA2964675	51	G>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1187843603 CA357276437	52	I>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
TCGA novel	52	I>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA357276461 rs1251193081	54	E>A		No	ClinGen gnomAD
rs969129902 CA99781288	55	P>H		No	ClinGen Ensembl
rs1165461746 CA357276509	58	G>R		No	ClinGen gnomAD
rs746043221 CA2964679	59	D>Y		No	ClinGen ExAC TOPMed gnomAD
CA2964680 rs770187364	60	V>L		No	ClinGen ExAC TOPMed gnomAD
rs370307359 CA2964682	63	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA357276578 rs1451922703	64	R>K		No	ClinGen TOPMed
CA99781321 rs201504507	66	F>C		No	ClinGen 1000Genomes
rs762413697 CA2964685	67	K>E		No	ClinGen ExAC gnomAD
rs762413697 CA357276613	67	K>Q		No	ClinGen ExAC gnomAD
CA99781330 rs747187698	67	K>R		No	ClinGen Ensembl
CA2964686 rs374054120	68	K>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA2964687 rs773676952	69	T>I		No	ClinGen ExAC gnomAD
CA357276659 rs1357958736	70	D>G		No	ClinGen gnomAD
rs1290405882 CA357276695	72	D>G		No	ClinGen gnomAD
rs1437544078 CA357276690	72	D>Y		No	ClinGen Ensembl
rs1217577854 CA357276716	73	R>S		No	ClinGen gnomAD
rs1239984611 CA357276727	74	S>N		No	ClinGen gnomAD
rs1485446441 CA357276735	75	A>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA357276777 rs1182262976	78	I>T		No	ClinGen gnomAD
CA357276838 rs1427880930	83	G>V		No	ClinGen TOPMed
rs1162774948 CA357276853	84	V>G		No	ClinGen gnomAD
CA99781367 rs1032001251	85	I>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA99781369 rs550412417	86	P>L		No	ClinGen Ensembl
rs1185337681 CA357276880	87	S>A		No	ClinGen gnomAD
CA2964692 rs184735609	88	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA357276900 rs1428532164	89	F>L		No	ClinGen gnomAD
rs143920365 CA357276927	90	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs1485344051 CA357276936	91	S>C		No	ClinGen TOPMed
CA2964695 rs146466349	92	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA99781426 rs992609176	93	Y>S		No	ClinGen Ensembl
CA2964696 rs764821469	94	H>Y		No	ClinGen ExAC TOPMed gnomAD
rs758253328 CA2964733	97	G>R		No	ClinGen ExAC gnomAD
CA357277097 rs1171854016	100	E>K		No	ClinGen gnomAD
rs374122301 CA99785158	101	K>E		No	ClinGen ESP TOPMed
CA99785165 rs912843175	103	H>D		No	ClinGen TOPMed gnomAD
CA357277120 rs1399009448	103	H>P		No	ClinGen TOPMed gnomAD
CA357277121 rs1399009448	103	H>R		No	ClinGen TOPMed gnomAD
rs764156773 CA2964735	104	C>S		No	ClinGen ExAC gnomAD
CA2964736 rs751546496	105	R>K		No	ClinGen ExAC
CA2964737 rs757059452	107	N>T		No	ClinGen ExAC
rs1334718216	107	N>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1405006310 CA357277154	108	F>L		No	ClinGen gnomAD
rs754083087 CA2964739	109	T>P		No	ClinGen ExAC gnomAD
rs778847279 CA2964741	110	L>H		No	ClinGen ExAC
CA2964742 rs748329307	111	K>E		No	ClinGen ExAC TOPMed gnomAD
rs1208295962 CA357277176	111	K>N		No	ClinGen TOPMed gnomAD
rs772052431 CA2964743	111	K>R		No	ClinGen ExAC
rs1272180011 CA357277181	112	T>I		No	ClinGen gnomAD
CA2964744 rs778198702	112	T>P		No	ClinGen ExAC gnomAD
CA2964747 rs771250612	113	V>F		No	ClinGen ExAC TOPMed gnomAD
rs771250612 CA2964746	113	V>I		No	ClinGen ExAC TOPMed gnomAD
CA99785270 rs940257830	116	T>A		No	ClinGen TOPMed
CA357277202 rs774856709 COSM1540832	116	T>I	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs774856709 CA2964750	116	T>S		No	ClinGen ExAC TOPMed gnomAD
CA2964751 rs139083562	118	Y>*		No	ClinGen ESP ExAC TOPMed gnomAD
CA99785283 rs1037011784	118	Y>C		No	ClinGen TOPMed gnomAD
rs536379368 CA2964752	119	N>S		No	ClinGen 1000Genomes ExAC gnomAD
CA2964753 rs751493402	121	H>L		No	ClinGen ExAC gnomAD
CA357277240 rs761881856	122	L>F		No	ClinGen ExAC TOPMed gnomAD
CA2964754 rs761881856	122	L>V		No	ClinGen ExAC TOPMed gnomAD
rs1295832732 CA357277280	128	C>F		No	ClinGen TOPMed gnomAD
CA357277276 rs755148803	128	C>G		No	ClinGen ExAC TOPMed gnomAD
rs755148803 CA2964757	128	C>R		No	ClinGen ExAC TOPMed gnomAD
rs1295832732 CA357277278	128	C>Y		No	ClinGen TOPMed gnomAD
rs149347484 CA2964758	129	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA2964759 rs752873556	130	E>K		No	ClinGen ExAC TOPMed gnomAD
rs777858301 CA2964762	133	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA2964763 rs76333976	135	Q>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs368339156 CA2964764	138	F>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA357277347 rs1368752856	138	F>V		No	ClinGen TOPMed
CA2964788 rs144642753	140	H>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs144642753 CA357276022	140	H>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2964789 rs201273807	141	S>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs773149389 CA2964790	141	S>N		No	ClinGen ExAC TOPMed gnomAD
CA2964792 rs148475724	145	M>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs1252127416 CA357276070	147	S>C		No	ClinGen gnomAD
rs763227582 CA2964794	148	P>L		No	ClinGen ExAC gnomAD
CA2964793 rs776343494	148	P>T		No	ClinGen ExAC TOPMed gnomAD
CA357276083 rs1319822320	149	K>E		No	ClinGen TOPMed
rs1429513255 CA357276103	151	L>P		No	ClinGen gnomAD
CA357276117 rs1393850287	153	H>R		No	ClinGen TOPMed
CA357276126 rs1560546272	154	K>E		No	ClinGen Ensembl
CA2964795 rs764370104	154	K>T		No	ClinGen ExAC TOPMed gnomAD
rs1358301665 CA357276185	158	V>M		No	ClinGen gnomAD
TCGA novel	160	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2964797 rs141771853	160	G>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs199945417 CA2964800	161	E>A		No	ClinGen 1000Genomes ExAC gnomAD
rs372598193 CA2964799	161	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs780452111 CA357276283	165	T>A		No	ClinGen ExAC gnomAD
CA2964802 rs749682280	165	T>K		No	ClinGen ExAC gnomAD
rs780452111 CA2964801	165	T>S		No	ClinGen ExAC gnomAD
CA357276317 rs1301028290	167	E>A		No	ClinGen gnomAD
rs773735442 CA2964805	170	R>P		No	ClinGen ExAC TOPMed gnomAD
rs773735442 CA99748828	170	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs375955767 CA2964804	170	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA357276371 rs1479393466	171	N>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA357276372 rs1479393466	171	N>T		No	ClinGen gnomAD
rs961779808 CA99748833	173	L>S		No	ClinGen TOPMed
rs369772476 CA2964806	175	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA357276421 rs1268913945	175	R>Q		No	ClinGen gnomAD
rs1252258694 CA357276438	176	E>G		No	ClinGen gnomAD
CA2964808 rs527900695	178	R>C		No	ClinGen ExAC gnomAD
rs770836249 CA2964809	178	R>H		No	ClinGen ExAC TOPMed gnomAD
CA2964810 rs776485319	180	Q>R		No	ClinGen ExAC gnomAD
CA357276530 rs867021462	182	S>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA99748862 rs867021462	182	S>L		No	ClinGen TOPMed
rs759261973 CA2964811	182	S>T		No	ClinGen ExAC gnomAD
rs150566447 CA2964812	183	L>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1303853321 CA357276581	185	K>N		No	ClinGen TOPMed gnomAD
CA99748872 rs969100352	186	T>A		No	ClinGen TOPMed
CA2964814 rs762054035	186	T>I		No	ClinGen ExAC gnomAD
rs1312980838 CA357276596	187	I>V		No	ClinGen TOPMed
rs1403413814 CA357276609	188	R>G	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs767553849 CA2964815	189	E>Q		No	ClinGen ExAC gnomAD
TCGA novel	190	L>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1363147609 CA357276636	190	L>V		No	ClinGen gnomAD
CA2964816 rs750526561	192	D>H		No	ClinGen ExAC gnomAD
CA2964817 rs761238889	194	C>R		No	ClinGen ExAC TOPMed gnomAD
CA357276725 rs1490695850	196	I>M		No	ClinGen gnomAD
CA99748882 rs928080935	196	I>V		No	ClinGen TOPMed
rs546553324 CA99748883	199	E>A		No	ClinGen 1000Genomes
CA2964819 rs148026447	201	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs140891870 CA2964820	202	N>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA357276813 rs1180329123	202	N>T		No	ClinGen Ensembl
CA2964821 rs779448314	203	R>I		No	ClinGen ExAC TOPMed gnomAD
CA2964822 rs752362349	206	T>S		No	ClinGen ExAC TOPMed gnomAD
CA2964823 rs180792819	207	F>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1250325732 CA357276920	210	D>N		No	ClinGen TOPMed
CA357276944 rs777327335	211	C>S		No	ClinGen ExAC TOPMed gnomAD
CA2964824 rs777327335	211	C>Y		No	ClinGen ExAC TOPMed gnomAD
CA2964826 rs770481500	212	C>W		No	ClinGen ExAC gnomAD
rs1208385138 CA357276976	213	Q>R		No	ClinGen TOPMed
CA99748906 rs766724371	214	E>*		No	ClinGen Ensembl
CA2964827 rs780935900	215	S>R		No	ClinGen ExAC gnomAD
CA357277015 rs1433094699	216	I>T		No	ClinGen gnomAD
CA2964828 rs745830472	217	E>G		No	ClinGen ExAC gnomAD
rs946767051 CA99748925	218	Q>R		No	ClinGen TOPMed
rs1560546655 CA357277040	219	D>E		No	ClinGen Ensembl
rs1419972445 CA357277033	219	D>N		No	ClinGen gnomAD
CA2964829 rs369485771	220	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD

No associated diseases with Q8TBB0

1 regional properties for Q8TBB0

Type	Name	Position	InterPro Accession
domain	THAP-type zinc finger	1 - 95	IPR006612

Functions

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

1 GO annotations of cellular component

Name	Definition
microtubule cytoskeleton	The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.

2 GO annotations of molecular function

Name	Definition
DNA binding	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
metal ion binding	Binding to a metal ion.

No GO annotations of biological process

Name	Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MVKCCSAIGC	ASRCLPNSKL	KGLTFHVFPT	DENIKRKWVL	AMKRLDVNAA	GIWEPKKGDV
70	80	90	100	110	120
LCSRHFKKTD	FDRSAPNIKL	KPGVIPSIFD	SPYHLQGKRE	KLHCRKNFTL	KTVPATNYNH
130	140	150	160	170	180
HLVGASSCIE	EFQSQFIFEH	SYSVMDSPKK	LKHKLDHVIG	ELEDTKESLR	NVLDREKRFQ
190	200	210	220
KSLRKTIREL	KDECLISQET	ANRLDTFCWD	CCQESIEQDY	IS