AiPD: Autoinhibited Protein Database

Q8TB03

Gene name	CXorf38
Protein name	Uncharacterized protein CXorf38
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:159013
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

25-95 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

25-95 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q8TB03

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8TB03-F1	Predicted				AlphaFoldDB

170 variants for Q8TB03

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
TCGA novel	3	L>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1326497887 CA412757693	4	S>P		No	ClinGen gnomAD
rs1162477471 CA412757639	7	A>S		No	ClinGen gnomAD
rs1419221605 CA412757622	7	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA10387514 rs774395912	8	A>P		No	ClinGen ExAC gnomAD
CA10387513 rs771151809	8	A>V		No	ClinGen ExAC gnomAD
CA10387512 rs749374090	9	R>G		No	ClinGen ExAC TOPMed gnomAD
rs1427415909 CA412757572	9	R>H		No	ClinGen TOPMed gnomAD
rs1427415909 CA412757564	9	R>P		No	ClinGen TOPMed gnomAD
CA412757539 rs1196026258	11	N>S		No	ClinGen gnomAD
CA412757521 rs1196765376	12	C>F		No	ClinGen gnomAD
rs960402647 CA328986675	12	C>R		No	ClinGen gnomAD
CA10387510 rs375122945	13	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA412757338 rs1348675258	18	W>C		No	ClinGen gnomAD
rs1227046913 CA412757348	18	W>S		No	ClinGen gnomAD
rs767570312 CA10387508 COSM1557572	21	A>T	lung [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC gnomAD
CA412757247 rs1368744129	24	C>Y		No	ClinGen gnomAD
CA412757222 rs6610447	26	L>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA10387506 rs6610447	26	L>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA10387503 rs753358236	29	R>H		No	ClinGen ExAC gnomAD
rs1428760364 CA412757144	30	S>G		No	ClinGen gnomAD
CA412756961 rs1175007410	37	G>D		No	ClinGen gnomAD
CA10387502 rs763594418	38	R>C		No	ClinGen ExAC TOPMed gnomAD
CA412756776 rs1393470723	45	R>C		No	ClinGen TOPMed gnomAD
rs967939741 CA328986595	45	R>H		No	ClinGen TOPMed gnomAD
CA10387501 rs760702332	46	G>D		No	ClinGen ExAC gnomAD
rs1248937227 CA412756747	47	L>P		No	ClinGen gnomAD
rs1486146252 CA412756742	48	L>V		No	ClinGen TOPMed gnomAD
CA412756716 rs767451859	49	A>S		No	ClinGen ExAC gnomAD
CA10387499 rs767451859	49	A>T		No	ClinGen ExAC gnomAD
CA10387498 rs774172659	50	A>G		No	ClinGen ExAC TOPMed gnomAD
CA412756696 rs1345574427	50	A>S		No	ClinGen TOPMed gnomAD
rs774172659 CA10387497	50	A>V		No	ClinGen ExAC TOPMed gnomAD
CA412756669 rs1392884467	51	A>G		No	ClinGen TOPMed
rs1392884467 CA412756668	51	A>V		No	ClinGen TOPMed
CA412756649 rs1239765456	52	P>L		No	ClinGen gnomAD
CA412756582 rs1433711299	56	P>L		No	ClinGen TOPMed
CA412756596 rs1337285278	56	P>T		No	ClinGen gnomAD
CA10387496 rs771114481	57	R>C		No	ClinGen ExAC gnomAD
CA412756555 rs1408794340	58	A>P		No	ClinGen TOPMed gnomAD
rs1408794340 CA412756559	58	A>S		No	ClinGen TOPMed gnomAD
rs1478082839 CA412756506	60	C>Y		No	ClinGen gnomAD
rs773167024 CA10387494	62	G>S		No	ClinGen ExAC TOPMed gnomAD
rs769803715 CA412756450	63	G>C		No	ClinGen ExAC TOPMed gnomAD
CA10387493 rs769803715	63	G>S		No	ClinGen ExAC TOPMed gnomAD
rs781697209 CA10387491	65	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA10387492 rs748673142	65	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1233808613 CA412756348	68	P>L		No	ClinGen TOPMed
rs1347255142 CA412756333	69	R>H		No	ClinGen TOPMed
CA10387489 rs747394149	70	A>G		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	70	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA412756310 rs1284197183	71	R>C		No	ClinGen TOPMed
rs1019310811 CA328986265	78	Q>R		No	ClinGen TOPMed
rs748925147 CA10387466	79	V>G		No	ClinGen ExAC gnomAD
CA412756079 rs1270224428	79	V>L		No	ClinGen gnomAD
CA328986252 rs1022641562	80	C>*		No	ClinGen Ensembl
rs1325131094 CA412756059	80	C>F		No	ClinGen gnomAD
rs777608701 CA10387464	81	A>T		No	ClinGen ExAC gnomAD
rs1397115520 CA412755600	82	E>D		No	ClinGen gnomAD
rs755805367 CA10387463	85	R>G		No	ClinGen ExAC gnomAD
rs988036372 CA328986223	88	L>F		No	ClinGen TOPMed gnomAD
CA10387462 rs752311318	90	H>L		No	ClinGen ExAC TOPMed gnomAD
rs752311318 CA412755467	90	H>R		No	ClinGen ExAC TOPMed gnomAD
rs780843289 CA10387461	91	H>D		No	ClinGen ExAC gnomAD
CA412755453 rs956786395	91	H>P		No	ClinGen gnomAD
rs956786395 CA328986193	91	H>R		No	ClinGen gnomAD
CA10387459 rs751453538	95	N>D		No	ClinGen ExAC TOPMed gnomAD
rs766106563 CA10387458	97	D>V		No	ClinGen ExAC gnomAD
rs750167376 CA10387456	99	H>Y		No	ClinGen ExAC gnomAD
rs899908254 CA328986184	100	W>*		No	ClinGen Ensembl
CA10387455 rs765505908	101	G>E		No	ClinGen ExAC gnomAD
rs1273278909 CA412755276	101	G>R		No	ClinGen gnomAD
rs762021259 CA10387454	102	N>K		No	ClinGen ExAC TOPMed gnomAD
CA10387453 rs776699513	103	C>Y		No	ClinGen ExAC gnomAD
TCGA novel	106	G>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA412755181 rs1256722215	107	R>C		No	ClinGen TOPMed
rs768666799 CA10387452	108	W>*		No	ClinGen ExAC gnomAD
rs761110465 CA10387451	110	V>M		No	ClinGen ExAC gnomAD
rs776025918 CA10387450	114	E>K		No	ClinGen ExAC gnomAD
CA412755098 COSM388024 rs1408477201	116	A>P	lung [Cosmic]	No	ClinGen cosmic curated gnomAD
rs750288425 CA10387434	120	M>L		No	ClinGen ExAC
CA412753565 rs1318840802	122	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs764948615 CA10387433	122	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA412753552 rs1286727783	123	G>R		No	ClinGen gnomAD
rs754012350 CA10387431	124	L>P		No	ClinGen ExAC TOPMed gnomAD
rs866436566 CA328982073	127	K>E		No	ClinGen Ensembl
CA10387428 rs775409361	133	C>Y		No	ClinGen ExAC gnomAD
CA328982049 rs867619527	136	V>F		No	ClinGen TOPMed
rs774859426 CA10387425	143	N>S		No	ClinGen ExAC gnomAD
rs945585403 CA328982033	146	D>E		No	ClinGen TOPMed
rs771360730 CA10387424	146	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA10387423 rs776378344	149	V>L		No	ClinGen ExAC gnomAD
rs776378344 CA10387422	149	V>M		No	ClinGen ExAC gnomAD
rs945134098 CA412752837	152	R>*		No	ClinGen TOPMed gnomAD
rs945134098 CA328982003	152	R>G		No	ClinGen TOPMed gnomAD
CA10387421 rs768158728	152	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs373499837 CA10387420	154	K>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs779429089 CA10387419	155	V>G		No	ClinGen ExAC
rs756581758 CA328981964	156	T>A		No	ClinGen TOPMed
CA10387417 rs145752299	157	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA10387407 rs774947484	160	K>T		No	ClinGen ExAC gnomAD
CA10387406 rs376500009	162	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA328980945 rs372043596	165	I>L		No	ClinGen TOPMed
CA412751741 rs1464873053	166	M>T		No	ClinGen gnomAD
rs1602423067 CA412751715	170	E>Q		No	ClinGen Ensembl
CA412751696 rs1235684151	172	K>*		No	ClinGen TOPMed
CA412751697 rs1235684151	172	K>E		No	ClinGen TOPMed
rs17145855 CA10387403 VAR_050936	176	T>A		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs746578704 CA10387402	176	T>M		No	ClinGen ExAC TOPMed gnomAD
rs775083103 CA10387401	178	L>P		No	ClinGen ExAC gnomAD
rs771435510 CA10387400	179	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA412751653 rs1309308943	179	R>Q		No	ClinGen TOPMed gnomAD
TCGA novel	180	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs745838892 CA10387399	183	M>I		No	ClinGen ExAC gnomAD
rs1226026088 CA412751601	186	Q>*		No	ClinGen gnomAD
rs1569270634 CA412751586	188	F>L		No	ClinGen Ensembl
CA412751546 rs1364399551	193	K>R		No	ClinGen gnomAD
CA412751529 rs1602422923	195	I>M		No	ClinGen Ensembl
rs778863045 CA10387398	195	I>V		No	ClinGen ExAC gnomAD
CA412751510 rs1251843759	198	I>T		No	ClinGen TOPMed
CA412751479 rs1388397578	203	S>A		No	ClinGen gnomAD
CA641464950 rs1292573635	206	E>I		No	ClinGen gnomAD
rs1195493029 CA412751452	207	Q>E		No	ClinGen TOPMed
CA10387396 rs146808310	207	Q>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs988206381	208	L>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM1467931 rs34678039 CA10387385	210	T>M	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs774967282 CA10387383	215	V>L		No	ClinGen ExAC gnomAD
rs1428531802 CA412751318	218	P>A		No	ClinGen gnomAD
rs773838974 CA10387380	219	E>K		No	ClinGen ExAC TOPMed gnomAD
rs372303197 CA10387379	220	E>K		No	ClinGen ESP ExAC gnomAD
rs1394617674 CA412751260	221	D>H		No	ClinGen TOPMed
rs749154771 CA10387378	223	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA10387377 rs777636638	223	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1249892251 CA412750935	231	G>E		No	ClinGen gnomAD
CA412750700 rs1486034020	238	Q>R		No	ClinGen gnomAD
TCGA novel	241	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1234698189 CA412750576	242	I>T		No	ClinGen TOPMed
CA10387374 rs781304930	248	K>R		No	ClinGen ExAC gnomAD
CA10387373 rs368399956 COSM1467930	249	E>D	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA412750425 rs1342823688	250	K>Q		No	ClinGen gnomAD
CA412750375 rs1255149514	252	Q>K		No	ClinGen gnomAD
rs1286054280 CA412750330	254	I>M		No	ClinGen TOPMed gnomAD
rs780221177 CA10387371	254	I>T		No	ClinGen ExAC gnomAD
CA10387370 rs758989465	255	Y>H		No	ClinGen ExAC TOPMed gnomAD
rs370266199 CA412750297 COSM1121238	256	L>I	Variant assessed as Somatic; 6.283e-05 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs370266199 CA328980686	256	L>V		No	ClinGen TOPMed gnomAD
CA328980680 rs1006208664	258	A>E		No	ClinGen Ensembl
CA412750154 rs1335653796	262	E>G		No	ClinGen gnomAD
CA10387369 rs374475948	264	L>F		No	ClinGen ESP ExAC gnomAD
CA10387354 rs769007634	271	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1602417100 CA412763245	275	V>A		No	ClinGen Ensembl
CA329008594 rs927084712	277	E>K		No	ClinGen Ensembl
rs756287646 CA10387353	280	R>G		No	ClinGen 1000Genomes ExAC gnomAD
rs780305790 CA10387352	283	E>*		No	ClinGen ExAC gnomAD
CA412762436 rs1319545095	284	D>G		No	ClinGen gnomAD
rs758515372 CA10387351	293	M>T		No	ClinGen ExAC gnomAD
rs142743216 CA10387350	294	Q>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs757769666 CA10387348	297	D>E		No	ClinGen ExAC gnomAD
rs779340340 CA10387349	297	D>G		No	ClinGen ExAC gnomAD
rs754223811 CA10387347	299	L>F		No	ClinGen ExAC gnomAD
CA10387345 rs754638331	304	K>*		No	ClinGen ExAC TOPMed gnomAD
CA412761957 rs1254146768	308	Q>*		No	ClinGen gnomAD
rs1189100289 COSM1714891 CA412761945	308	Q>H	skin [Cosmic]	No	ClinGen cosmic curated gnomAD
rs141391425 CA10387344	309	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs765901389 CA10387343	313	Q>*		No	ClinGen ExAC TOPMed gnomAD
rs147827701 COSM3379627 CA10387342	313	Q>H	pancreas [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs954659521 CA329008521	316	D>E		No	ClinGen Ensembl
CA412761846 rs1291570538	317	R>G		No	ClinGen gnomAD
CA329008517 rs992939283	318	K>N		No	ClinGen TOPMed
CA412761817 rs1264748272	320	A>R		No	ClinGen TOPMed

No associated diseases with Q8TB03

No regional properties for Q8TB03

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q8TB03

Functions

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

No GO annotations of cellular component

Name	Definition
No GO annotations for cellular component

No GO annotations of molecular function

Name	Definition
No GO annotations for molecular function

No GO annotations of biological process

Name	Definition
No GO annotations for biological process

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q8C5K5		Uncharacterized protein CXorf38 homolog	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MVLSELAARL	NCAEYKNWVK	AGHCLLLLRS	CLQGFVGREV	LSFHRGLLAA	APGLGPRAVC
70	80	90	100	110	120
RGGSRCSPRA	RQFQPQCQVC	AEWKREILRH	HVNRNGDVHW	GNCRPGRWPV	DAWEVAKAFM
130	140	150	160	170	180
PRGLADKQGP	EECDAVALLS	LINSCDHFVV	DRKKVTEVIK	CRNEIMHSSE	MKVSSTWLRD
190	200	210	220	230	240
FQMKIQNFLN	EFKNIPEIVA	VYSRIEQLLT	SDWAVHIPEE	DQRDGCECEM	GTYLSESQVN
250	260	270	280	290	300
EIEMQLLKEK	LQEIYLQAEE	QEVLPEELSN	RLEVVKEFLR	NNEDLRNGLT	EDMQKLDSLC
310
LHQKLDSQEP	GRQTPDRKA