Q8T6J1

PR
Gene name
abcA6 (DDB_G0291245)
Protein name
ABC transporter A family member 6
Names
ABC transporter ABCA.6
Species
Dictyostelium discoideum (Slime mold)
KEGG Pathway
ddi:DDB_G0291245
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

51-121 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8T6J1

Entry ID Method Resolution Chain Position Source
AF-Q8T6J1-F1 Predicted AlphaFoldDB

No variants for Q8T6J1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8T6J1

No associated diseases with Q8T6J1

8 regional properties for Q8T6J1

Type Name Position InterPro Accession
domain ABC transporter-like, ATP-binding domain 491 - 724 IPR003439-1
domain ABC transporter-like, ATP-binding domain 1309 - 1544 IPR003439-2
domain AAA+ ATPase domain 519 - 709 IPR003593-1
domain AAA+ ATPase domain 1339 - 1523 IPR003593-2
domain ABC-2 type transporter, transmembrane domain 22 - 432 IPR013525-1
domain ABC-2 type transporter, transmembrane domain 866 - 1258 IPR013525-2
conserved_site ABC transporter-like, conserved site 626 - 640 IPR017871-1
conserved_site ABC transporter-like, conserved site 1446 - 1460 IPR017871-2

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

4 GO annotations of molecular function

Name Definition
ABC-type transporter activity Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATPase-coupled transmembrane transporter activity Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source.
lipid transporter activity Enables the directed movement of lipids into, out of or within a cell, or between cells.

2 GO annotations of biological process

Name Definition
lipid transport The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
sorocarp morphogenesis The process in which the sorocarp is generated and organized. An example of this process is found in Dictyostelium discoideum.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEFGRQLKTL LKKNLLLKGK SKCSICCEIV FPIVIIGVLF AILALIKVTN SDYNSIDVTT
70 80 90 100 110 120
FSRRVGPENK LLYGSEGSLN NDQSGVIETM KEQVATARGL TVAEVQDFFM EINDRTLMES
130 140 150 160 170 180
FFKNYSMMVY GGVWFNSSTN GGGGGNNNDP IAAGGQFGYN IRLDSDDTAD TSETGKVDGG
190 200 210 220 230 240
DSSIYLNDNF ASIQVAMDQA IFGYFGLDMV LNISGRHYPD PYTELWQEWI TGRDAIIKSA
250 260 270 280 290 300
GSVFITAALM MFSFRLVTDV VIEKETKIVE AMRMMSLNSL AYFSSWIITS LITSLPVTLL
310 320 330 340 350 360
IVVIFKGSQL IYSTSWGIVI ITFVLYLITL LLLSFIFSIF FNNSKFCGLL SFVIVIAINI
370 380 390 400 410 420
CGIFVSKNEF SVSVKLLLSI FSPIAFSNSI YIMSVKDLTM ILNLNWDYIV TENQSILMLG
430 440 450 460 470 480
IDIIIYIILI WYFEKVIPGE YGTKEKFYFL FTKNYWFGKK RSIGEIDDIE STFDSEDVET
490 500 510 520 530 540
IPLKVLKNST ISIRNLRKEF ETGDGLRVAV NDLYLDMFED QIHALLGPNG CGKSTTIGML
550 560 570 580 590 600
TGLISPTSGS AFIRGYDITS QMSKIRPYIG CCLQTDIIWS QLTVLEHLVI YASLKGVEGR
610 620 630 640 650 660
NIQREAERMA TEVGLAEKMN APAGSLSGGQ KRKLCLGIAF IGRSKIIFLD EVTSGMDPVS
670 680 690 700 710 720
RRQVWDFLLK YKKGKTIILT THYLEEADYL GDRIAIISQG KLRCDGTSLF LKNRFGQGYL
730 740 750 760 770 780
LTCNKKLENA SNGFNTNQVS EFIKNFIPGA SILTDSGAEL SYRLPTESLS NFPQFFTEFD
790 800 810 820 830 840
LNLSKFSIQT YGISVTSLEE VFISLGQEDS KKLNNNANGN NEFNKQNEME SLKLAIATPS
850 860 870 880 890 900
DGINQIQQFK GLLIKRIQQS KKDARSFFLS IILPMALIIG SIILYKSMND QKQVLFYNNS
910 920 930 940 950 960
TQPLTMSLSI YTDSDNTINV PMQLLNNELE WSNLFNNSPY FNKFKYINES INFNDYLIDN
970 980 990 1000 1010 1020
YKLSIGAINF TNQPISIDDN NNGQSTNCSY IAYYNSDYIH SFPIHVNLIN DALLRKFKNI
1030 1040 1050 1060 1070 1080
SISVTSMPFD HILTAFEISS SDINASAIIY FVFILMAGFS LMAGSFAGSI AQERTNRVKR
1090 1100 1110 1120 1130 1140
LLYVSGCKKH IYWLSNLVWD FFFAFIISIL SCSILAGVIK GAFKEQFGSF LLCLILLSCA
1150 1160 1170 1180 1190 1200
IIPLGYLMSY KFQTYGKAVG AITAILFVFG LVFTIASLNV RIQAVVNQNS TTQKVADIID
1210 1220 1230 1240 1250 1260
LIFSIISPIF ALNRIVFILS GFPGSTRLGT FKVDNYWSFD YLGTPLIVLA GHAVLWNVWI
1270 1280 1290 1300 1310 1320
LLLDYVPQIK GFFKNPKNLP APSPPQDEDY DVSQERRRLL NMRPSEEPIQ FKNLHKLFPG
1330 1340 1350 1360 1370 1380
SGKNPSKTAV YNSTLGIPRG QTFGLLGLNG GGKSTTLSML SGEIVPSSGE ISINGYDVIT
1390 1400 1410 1420 1430 1440
NREKALGNIS MVFQFDALIS LLSAREHLWL FSRIKGIKES QIENCVEAFI KMVDLTRIAN
1450 1460 1470 1480 1490 1500
SGCGGYSGGN KRKVSLSMAM LGNPSVCFLD EISCGCDAVV RRQLWDVISE LGKDKSIILT
1510 1520 1530 1540 1550 1560
SHSMSEVEAL CSRITIMKEG KYTCLNTIQG VKNRFGAGYS IDVKFKKEYL ETGIQTILQS
1570 1580 1590 1600 1610 1620
IPNCTVLDQH DVMASFEVPN PPGNPIKLSN IFSILSNLPI LDDYNVGQTS LESVFLKLTG
1630
ANHDQRINLY D