Q8T2I8

PR
Gene name
sepA
Protein name
Serine/threonine-protein kinase sepA
Names
Septase A
Species
Dictyostelium discoideum (Slime mold)
KEGG Pathway
ddi:DDB_G0276465
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

249-644 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

157-178 (Activation loop from InterPro)

Target domain

18-268 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q8T2I8

Entry ID Method Resolution Chain Position Source
AF-Q8T2I8-F1 Predicted AlphaFoldDB

No variants for Q8T2I8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8T2I8

No associated diseases with Q8T2I8

No regional properties for Q8T2I8

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q8T2I8

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
centrosome A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein kinase activity Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

5 GO annotations of biological process

Name Definition
cleavage furrow formation Generation of the cleavage furrow, a shallow groove in the cell surface near the old metaphase plate that marks the site of cytokinesis. This process includes the recruitment and localized activation of signals such as RhoA at the site of the future furrow to ensure that furrowing initiates at the correct site in the cell.
mitotic cytokinesis A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells.
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of pseudopodium assembly Any process that modulates the frequency, rate or extent of the assembly of pseudopodia.
sorocarp development The process whose specific outcome is the progression of the sorocarp over time, from its formation to the mature structure. The process begins with the aggregation of individual cells and ends with the mature sorocarp. The sorocarp is a structure containing a spore-bearing sorus that sits on top of a stalk. An example of this process is found in Dictyostelium discoideum.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSKKEPEEIK KNVTVGNYNL GVVIGKGGFG TVYQGLDIED GDFVAIKQIN LTKIPKDQLQ
70 80 90 100 110 120
GIMNEIDLLK NLNHANIVKY IKYVKTKDNL YIVLEYVENG SLSGIIKKFG KFPETLVCVY
130 140 150 160 170 180
IRQVLEGLVY LHEQGVVHRD IKGANILTTK EGKIKLADFG VATKFDDTSA AAVVGTPYWM
190 200 210 220 230 240
APEIIELNGA TTKSDIWSVG CTVIELLTGS PPYYDLGQMP ALFRIVQDDC PPLPEGISPP
250 260 270 280 290 300
LKDWLMQCFQ KDPNLRISAQ KLLKHKWIQA SIKKKPVENG AGGVGNGTDS LGAPANIDDI
310 320 330 340 350 360
AKNITDYNER INKKPSHQRK PSIHPKSPKG KVFLPPPEEE EDEWGDDFSN TPKSIKLPDK
370 380 390 400 410 420
KSPLKLTNNK PSTPLKQQPT NNTPVQQQQQ QQQPPPLKLA VPKQPVIEND DDWGDDFNTV
430 440 450 460 470 480
SDLSKAVGSL NFNNNKKNET PKPNIKKPTF SEDEDEDDDD DGFGSGGDDE DDDFGDIPTS
490 500 510 520 530 540
IKLNPKFGSN IKGNSSGSAN TTNSSSTVVQ QPKLTVSNNN NNNNKKLPLS PRQPSSGNVK
550 560 570 580 590 600
EGINHGSTGS KSGGVIIDQW GEDGEEDNDW GDVATVNFDP KVIRKGTVNK PDLSTRLKNR
610 620 630 640 650 660
IALSETALSN SFNNNGNDDE DEDIFADDFD EDDDEDFDLD KNLMKDNYAR MSSEILKLMN
670 680 690 700 710 720
LLTPEQPEEV ISSACTQLIT MFKENSEQKT LLIRRHGVIP IMEMLEVSNI QSHVLCSILK
730 740 750 760 770 780
VVNQIIDNNM EIQENLCLVG GIPAIMKFSG PEYPASVRLE TASFISKMCS TSTLTLQMFI
790 800 810 820 830 840
ACKGLPILVD FLLSPYAESK RLVWMAVDAI VNVFELQSPT PKNDFCRLFS KCGLLKTLPI
850 860 870 880 890 900
VLRDSIADGE AAATYPDRII NLFIMFSAAD SVVRKTMSAV EVIRPILDTL SQLMPEQLAK
910 920 930 940 950 960
VLKSIKQLSM DHNTLANLQN AGAIRFMVPF LGRRTGAFVA EIHNHVLNTM FHLCRIDPER
970 980 990 1000 1010 1020
QYQAAIDGII PHLQYFITSH SPLNQFALPI ICDLAHSKKA RSELWKNNGV AFYLSLLEER
1030 1040 1050 1060 1070 1080
YWQVNALDSL AVWITDETHK VENIIATNEN IKKLIQLFTN AESQSFAGIL EPLLKIIQIS
1090 1100 1110 1120 1130 1140
IPVNILLGTS NFITKIIDKL GHTNPQVRLN LLKIITSLYE CHPNAKKMIQ EFKLIPIIQK
1150 1160
IADTDKSVLV QKMASKLLEA FNANTVI