Q8SSV3

PR
Gene name
mkcD
Protein name
Probable serine/threonine-protein kinase mkcD
Names
MAP kinase cascade D
Species
Dictyostelium discoideum (Slime mold)
KEGG Pathway
ddi:DDB_G0277413
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

168-377 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

511-533 (Activation loop from InterPro)

Target domain

369-626 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q8SSV3

Entry ID Method Resolution Chain Position Source
AF-Q8SSV3-F1 Predicted AlphaFoldDB

No variants for Q8SSV3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8SSV3

No associated diseases with Q8SSV3

2 regional properties for Q8SSV3

Type Name Position InterPro Accession
domain Protein kinase domain 369 - 626 IPR000719
active_site Serine/threonine-protein kinase, active site 490 - 502 IPR008271

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

1 GO annotations of biological process

Name Definition
protein phosphorylation The process of introducing a phosphate group on to a protein.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNNIKSFFGK KKKTQDQAEP LVIGDDSEKR TVILPPPSPN AVKRKNKNEK PYSIDLNGVG
70 80 90 100 110 120
EVGGKVYNNV VGVFADGNDT GEISPTIYCV SDFQGLLKND RKWIQYSELP EGYTVFYFQT
130 140 150 160 170 180
ILCVLNFLRR REFVHYIYVD KFEQILEMNE NNENIITTVI PTNPIDENDK INSKSINDGD
190 200 210 220 230 240
DNGGGSGGGG DNSPLTNVIL PTITTTDTTT TSITISPPPK NHLSLLEEDI KNNQNLHHKQ
250 260 270 280 290 300
QQLQQLQQLK QQHLQQQQKL KQEQQQEQQQ QQEDEPNKSP VSTSSTLSPQ LESTNFEMTN
310 320 330 340 350 360
DDTSLNAPNA MLTPNNISGI SYSIIYPGKK KRIDFSRIFV SPGHSFRFPE EYDKALEKHL
370 380 390 400 410 420
NEGNPKEHFK NLDFEARGGF GSVFCAKNKN PHSAYDKQMV ALKKMPIKTL RHKRMNLSEI
430 440 450 460 470 480
GFLKYFNHPN IVKFLCAYQK SNDELWMIME FLSGGTLKNA ASNFKFCERK IAYVCREILQ
490 500 510 520 530 540
GLDYLHKQNI AHRDLKSANV MVNDKGEIKL IDFGLCIDFS IEKEEINMLG SPSYISPEMI
550 560 570 580 590 600
NGNPHSLSTD IWSFGICALE MLLGKLPYHD SRLKAMVFVA TNNLNLPLLL STTTSSLEFR
610 620 630 640 650
DFLTNCLQFD PSKRLTSSQL LQHPFLTKAC PIKDFKEILP ALYMSNTLSN MF