Q8SSH4

PR
Gene name
MPS1 (ECU02_0510)
Protein name
Probable serine/threonine-protein kinase MPS1 homolog
Names
Monopolar spindle protein 1
Species
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
KEGG Pathway
ecu:ECU02_0510
EC number
2.7.12.2: Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-58 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

423-448 (Activation loop from InterPro)

Target domain

289-540 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q8SSH4

Entry ID Method Resolution Chain Position Source
AF-Q8SSH4-F1 Predicted AlphaFoldDB

No variants for Q8SSH4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8SSH4

No associated diseases with Q8SSH4

4 regional properties for Q8SSH4

Type Name Position InterPro Accession
domain Protein kinase domain 289 - 540 IPR000719
active_site Serine/threonine-protein kinase, active site 403 - 415 IPR008271
binding_site Protein kinase, ATP binding site 295 - 316 IPR017441
domain Protein kinase Mps1 family, catalytic domain 287 - 540 IPR027084

Functions

Description
EC Number 2.7.12.2 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
MAP kinase kinase activity Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein tyrosine kinase activity Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

2 GO annotations of biological process

Name Definition
chromosome separation The cell cycle process in which paired chromosomes are detached from each other. Chromosome separation begins with the release of cohesin complexes from chromosomes; in budding yeast, this includes the cleavage of cohesin complexes along the chromosome arms, followed by the separation of the centromeric regions. Chromosome separation also includes formation of chromatid axes mediated by condensins, and ends with the disentangling of inter-sister catenation catalyzed by topoisomerase II (topo II).
organelle organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEGIFNSKSL YEYLEEQKQA GISKTKEISL YYKATSKSVG DDEYSLRIWL DYIRLLMDGT
70 80 90 100 110 120
KDVTEARETF KMIKMRFCKF YNYWEAYVRF EIEAGNGSLC KILQHSIDFV KVKEFTEKKR
130 140 150 160 170 180
VLEYLECVMS YARNGEDLSV FCRGPETSFK PGAQVLSPFE ARIGEQSKNK VLKKEHEESG
190 200 210 220 230 240
PGHRDDGKNL LSRSGRAHLA PDECKENDNK NRAREDGASL SPSFAAKSKN CGATFGTIPI
250 260 270 280 290 300
RFEKEDYSQG ITMEINAALG RTSPEGSNSS PRSGAVRSRE RIIIKGREIE ILKQIGKGGS
310 320 330 340 350 360
SKVYKVLFGS NVYALKRVEL IGDEKMLSSY INEINLLYKF KGTSEIVEII DHEVGEDYLH
370 380 390 400 410 420
ILLEYGETDL SKIIRKGGLS MNFIKDVWEQ MLLIVKRVHI ERIIHCDLKP ANFLFVKGRV
430 440 450 460 470 480
KLIDFGISKV IRNDTTSILS EEQCGTVNYM SPEAVTQNKS KVARSSDIWS LGCILYEMVH
490 500 510 520 530 540
SNPPLHEYPN LIQKIQRLQE YSEFKYTSKN KAAVMVMKEC LARDPKKRPT IDNLLNHRFL
550 560 570 580
TGEMCLESLR ELVEKILKID GGDRVDPEHV DRIAEQLHST HRQDQA