Q8SSE7
PR
Gene name |
MEC1 (ECU02_1130) |
Protein name |
Probable serine/threonine-protein kinase MEC1 homolog |
Names |
ATR homolog, DNA-damage checkpoint kinase MEC1 homolog |
Species |
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite) |
KEGG Pathway |
ecu:ECU02_1130 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8SSE7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8SSE7-F1 | Predicted | AlphaFoldDB |
No variants for Q8SSE7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q8SSE7 | |||||
No associated diseases with Q8SSE7
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| chromatin organization | The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA. |
| DNA repair | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. |
| meiotic cell cycle | Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions. |
| phosphorylation | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNRDYLKNLY | LQRLESERYS | DVFRESMSSL | VSTEIINAVI | SLAVQDDDET | MLVDLLELFL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QNLESNVVFH | EKLTKSSFHL | LLFKRPLGIQ | SYTKLKSIYD | RVGSRRVVPG | FEHTEFLSKN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FYNYCLYKHA | YKDYQFDLEL | DAGSLGPVET | NLFKDLLKAV | CIENRENEHL | ANYIKTLPMD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VSVFLAIVMP | DFRIDASRLG | PEDVFLVCPS | QVRGYDPKQF | TKAFLCSLNS | EGGLCRVCGR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RVLGCGFEEI | DREEYLDSVS | GNIEEMCFGV | SHWEKIRTPR | MLTTILRSLF | KRPGCLECYK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| CLRYFPIEEQ | GEMEDIVLRF | LRYAASILSI | GNIQVSLRMF | PFIRHTPRVV | FSYFVILFEG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FLKYSGNLFL | KNVIRNVSTR | NKAKFMGVRA | MIFEYYLKGS | IESASSTEEN | TKNEGGSGAV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ENPGRKRADD | LGDLFAPLSE | FFDEERKAFV | RNNMFYIYPI | MYSLSFPYYT | PDLAFTQANN |
| 490 | 500 | 510 | 520 | 530 | 540 |
| HFLIISLFLR | GEESRIDEIG | YGKDELYRMG | VDVMIPLLCN | GYFKYDVLSR | FFGNVQEYIR |
| 550 | 560 | 570 | 580 | 590 | 600 |
| AHLPKFLFAL | KKVYVERPFE | FRVCVFKILK | CIIEAISGNV | RMLFNYLFPF | VEFFMRSHEE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| SCGTDCKMIF | IEYYSSFFKN | DCLVRNMSRI | FPYLDAEKIA | RWSNVKSEDD | YLDIVIGLLD |
| 670 | 680 | 690 | 700 | 710 | 720 |
| TRGHFSQEMA | AKKAVELLAR | VFGDPGKGKG | FDEESFVENV | LRRFFKSREF | RMKIGNVYGK |
| 730 | 740 | 750 | 760 | 770 | 780 |
| LKELGNDAAF | LIGCISQEFL | DANPLPSVCS | VLIEECTPEA | IARVMVEKYL | FEMDPGKQDL |
| 790 | 800 | 810 | 820 | 830 | 840 |
| HFFIIQETLR | FIKGPLSDRM | EEVVEQFRST | QYFYEYVPVH | PVEGVYEKTY | TFKRFLGRLY |
| 850 | 860 | 870 | 880 | 890 | 900 |
| RYSLNEIAKS | EMQEYFSLLK | YGNLLDTLFL | EFHCLCLCRL | LLEAGDHKVL | GMVREIANNL |
| 910 | 920 | 930 | 940 | 950 | 960 |
| QEGVDKRIAR | FVLKLHGFTS | GKHIEDQQIL | RISFFLKDHH | NAIQTLEKMI | RKERKSELFD |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| LLQYCYYSIK | DYDKVLGINS | VFARPSLINL | FFRFCVDKNF | AAARRCLEPK | PGHDGVKEES |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| GEDHKGQAPR | ELDVKILMEE | IIDECQDDEV | TKFMNDCKKI | EGDFSEWKRL | ESRNEVFKHF |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| IKDCELVSKS | KNLLKTLDLI | AGRRELAGDN | RMLLECHESL | VASIRSMMDA | RDDMSCDEMF |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| ESLLTAEKQD | TIGNSSQGLH | SREYFDDFAS | VDMVRAERRS | ERIGYMDRSK | SGSTSGYSSL |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| EEFERDLKLA | IIRNYRGDDD | VGRCIQEIGG | MLLKREWCVL | YELAELNVLQ | GKIGDAKTSL |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| KKVLEIFPKT | SMLYKKALIR | YSELLDTKTA | YTSALSILKD | SGKLFLLGAK | KFESTEPVKA |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| MEMYINSVIH | DNQCSDEAVP | RIFHLFSEMM | PPGDINAGAV | LLKKFLESSI | SLLPPYYNQI |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| LSRLSHPNQD | VANVVSRIVF | ELMENYPSKT | FWRSLIMMNS | QVPSTRKRME | GIVSGLTLDN |
| 1450 | 1460 | 1470 | 1480 | 1490 | 1500 |
| KVALSNVKRI | SEELTCISRS | KKNELTMEED | FPAFAKMFPA | GVTVPNTKVL | ISGVRNEVKV |
| 1510 | 1520 | 1530 | 1540 | 1550 | 1560 |
| FNSLQRPKRI | CFVGSDGKNY | YWLCKNQDDL | RKDSRFMDLN | LIINSILKKQ | SSRKYIRTYA |
| 1570 | 1580 | 1590 | 1600 | 1610 | 1620 |
| VIPFSHESGI | IEWIGGLSSL | KAICDTYYAR | DGISISETAC | RFVHNKKIGM | REWHRVASKF |
| 1630 | 1640 | 1650 | 1660 | 1670 | 1680 |
| HPKFHLWFHD | SFPHPFSWLV | ARNNYTQTYA | IMNIVGWFMG | LGDRHAENIL | FDSNTGDTVH |
| 1690 | 1700 | 1710 | 1720 | 1730 | 1740 |
| VDLNCIFGKG | KELQVPERVP | YRLTQNIVDA | FGVLGLEGSY | NTSLCTTLDL | FLKNKNILVS |
| 1750 | 1760 | 1770 | 1780 | 1790 | 1800 |
| NLLSFVYDPL | FEWRRKSATT | PKKIIEDLWH | KMDDLDACSK | CDVLNEEATN | DENLCMMYIG |
| WLPFI |