Q8SQZ4

PR
Gene name
YAK1 (ECU11_0180)
Protein name
Probable dual specificity protein kinase YAK1 homolog
Names
Species
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
KEGG Pathway
ecu:ECU11_0180
EC number
2.7.12.1: Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

318-405 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

182-202 (Activation loop from InterPro)

Target domain

40-360 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q8SQZ4

Entry ID Method Resolution Chain Position Source
AF-Q8SQZ4-F1 Predicted AlphaFoldDB

No variants for Q8SQZ4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8SQZ4

No associated diseases with Q8SQZ4

3 regional properties for Q8SQZ4

Type Name Position InterPro Accession
domain Protein kinase domain 40 - 335 IPR000719
active_site Serine/threonine-protein kinase, active site 159 - 171 IPR008271
binding_site Protein kinase, ATP binding site 46 - 68 IPR017441

Functions

Description
EC Number 2.7.12.1 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
Subcellular Localization
  • Cytoplasm
  • Nucleus
  • Shuttles between both compartments in response to glucose
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine/threonine/tyrosine kinase activity Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
protein tyrosine kinase activity Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKKKVLTFPS EKIGFSSDNE EFDLVMARGD YLAKNKSQKY MIIDMLGTGT FGQVVRCVGS
70 80 90 100 110 120
DGEEVAIKVV KNQPKYYNYE MNEVRILHKL LYNNLNDRFV TIKDVFMYKQ HLCIVEELLG
130 140 150 160 170 180
RNLYTFLKMT RFKGLDHPTL RTILHQILEG MVQLSLLGII HCDLKPENIL IADYDTFKIK
190 200 210 220 230 240
IIDFGSAVTS PQGSHFYVQS RYYRAPEVIL GIPYGSSCDI WSLGCIGYEL YVGHPLFPGK
250 260 270 280 290 300
DNMDQIGRIH GLFGSLPMFM LEHGKNSSTF FEKENGYRFM GPPSNFTLED MKKMIRSKGN
310 320 330 340 350 360
SKEDDNMLIK FLLRALQPSH LIRPDAKSLA SHSYLKVRDT SAEADKACND RSGVQQNIFP
370 380 390 400
ANKNMRHMST TGVILPSKKQ KPTDDRRKIS VYGISYENNL NRDSE