Q8SQW2

PR
Gene name
CTK1 (ECU11_0960)
Protein name
Probable CTD kinase subunit alpha homolog
Names
CTDK-I subunit alpha, CTD kinase subunit 1
Species
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
KEGG Pathway
ecu:ECU11_0960
EC number
2.7.11.23: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-49 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

156-178 (Activation loop from InterPro)

Target domain

22-297 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q8SQW2

Entry ID Method Resolution Chain Position Source
AF-Q8SQW2-F1 Predicted AlphaFoldDB

No variants for Q8SQW2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8SQW2

No associated diseases with Q8SQW2

3 regional properties for Q8SQW2

Type Name Position InterPro Accession
domain Protein kinase domain 22 - 297 IPR000719
active_site Serine/threonine-protein kinase, active site 135 - 147 IPR008271
binding_site Protein kinase, ATP binding site 28 - 49 IPR017441

Functions

Description
EC Number 2.7.11.23 Protein-serine/threonine kinases
Subcellular Localization
  • Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
RNA polymerase II CTD heptapeptide repeat kinase activity Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (YSPTSPS) = ADP + H+ + phosphorylated RNA polymerase II.

2 GO annotations of biological process

Name Definition
mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
protein phosphorylation The process of introducing a phosphate group on to a protein.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEPAEEGEIL AHRRFTATKM EYEKIRIIGE GTFGQVILAR KGRARYALKK VSKEKEGLSV
70 80 90 100 110 120
TTIREVQVLR AMGHPSIVRL IEVVVEPGGD IYMVFPYFPY DLNRFIRSNK MTCSEIKHIF
130 140 150 160 170 180
YQIAQGVCYI HSKGIMHRDL KSANILLDQK LNASIADFGM ARYTTKTGAY TPGMVTLWYR
190 200 210 220 230 240
APEILLGSSS YTYAVDIWSL GCILTEMYLG HMIFQGSTEM LQLEMVIHAC GSINENSYPG
250 260 270 280 290 300
VQDLPGFRNF RLPQSPRRIE GIIRKHDASA VELVSKMLCL DPSKRITVEQ VVGSKYFEHE
310 320
ARRDASSAGL QGCSYREDRL SLSKRKNVD