Q8SQR2

PR
Gene name
ECU11_1980
Protein name
Probable casein kinase I homolog ECU11_1980
Names
Species
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
KEGG Pathway
ecu:ECU11_1980
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

185-260 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8SQR2

Entry ID Method Resolution Chain Position Source
AF-Q8SQR2-F1 Predicted AlphaFoldDB

No variants for Q8SQR2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8SQR2

No associated diseases with Q8SQR2

2 regional properties for Q8SQR2

Type Name Position InterPro Accession
domain Protein kinase domain 8 - 306 IPR000719
binding_site Protein kinase, ATP binding site 14 - 37 IPR017441

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

2 GO annotations of biological process

Name Definition
DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
protein phosphorylation The process of introducing a phosphate group on to a protein.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRGEIMDYTI CREIGKGGFG KVYEVKKKAD QKSYALKIET NAPKAGRNSI INEIQAYSEL
70 80 90 100 110 120
QGCEKIPRLV DHGSYEGLTF LVLPLLKYSL KDLLERHPRF FTKKSATIVG KKLLNAIEFI
130 140 150 160 170 180
HGKGRLHRDI KPENVMFGHN NRIYLVDFGM SAPYLRGDGS HIPEVGGKSV SGTLWYMSIN
190 200 210 220 230 240
THRGIEQSRR DDLESLFYLL ILLYKSRLPW MEPGASVSKK QEARTKEIKE NLSVYDLCDG
250 260 270 280 290 300
IHGKEHLIKF FQHISSLEFA EKPNYRYLNS LLDKIFHSNK ELQGYKRAPK KEDTGLIRTS
310
LWHKFISILS PFEVKYDG