Q8S950

PR
Gene name
NACK1
Protein name
Kinesin-like protein NACK1
Names
NPK1-activating kinesin-1
Species
Nicotiana tabacum (Common tobacco)
KEGG Pathway
nta:107780313
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-51 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8S950

Entry ID Method Resolution Chain Position Source
AF-Q8S950-F1 Predicted AlphaFoldDB

No variants for Q8S950

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8S950

No associated diseases with Q8S950

3 regional properties for Q8S950

Type Name Position InterPro Accession
domain Kinesin motor domain 28 - 361 IPR001752
conserved_site Kinesin motor domain, conserved site 251 - 262 IPR019821
domain NPK1-activating kinesin-like protein, C-terminal 777 - 939 IPR021881

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
  • Cytoplasm, cytoskeleton, phragmoplast
  • In interphase and prophase, detected in the nucleus
  • From prometaphase to metaphase, found in the cytoplasm in patches
  • At anaphase, distributed around the spindle midzone and on the phragmoplast equator at telophase
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
phragmoplast Fibrous structure (light microscope view) that arises between the daughter nuclei at telophase and within which the initial partition (cell plate), dividing the mother cell in two (cytokinesis), is formed. Appears at first as a spindle connected to the two nuclei, but later spreads laterally in the form of a ring. Consists of microtubules.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
microtubule binding Binding to a microtubule, a filament composed of tubulin monomers.
microtubule motor activity A motor activity that generates movement along a microtubule, driven by ATP hydrolysis.

2 GO annotations of biological process

Name Definition
cell plate assembly The process of assembly, maturation, and growth of the cell plate to the cell periphery in cells that divide by cell plate formation; often involves deposition of cell wall material in and around the phragmoplast.
microtubule-based movement A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTVRTPGTPA SKIDKTPATT PNGHRGREEK IVVTVRLRPL NKRELSAKDH AAWECIDDHT
70 80 90 100 110 120
IIYRPVPQER AAQPASSFTF DKVFGPDSIT EAVYEEGVKN VALSSLMGIN ATIFAYGQTS
130 140 150 160 170 180
SGKTYTMRGI TEKAVNDIYA HIMSTPEREF RIRISGLEIY NENVRDLLNS ESGRSLKLLD
190 200 210 220 230 240
DPEKGTVVEK LVEETASNDQ HLRHLISICE AQRQVGETAL NDTSSRSHQI IRLTIESTLR
250 260 270 280 290 300
ESSDCVRSYV ASLNFVDLAG SERASQTNAD GARLREGCHI NLSLMTLTTV IRKLSVGKRS
310 320 330 340 350 360
GHIPYRDSKL TRILQHSLGG NARTAIICTL SPASSHVEQS RNTLYFATRA KEVTNNAQVN
370 380 390 400 410 420
MVVSDKQLVK HLQKEVARLE AELRTPDPAN EKDWKIQQME MEIEELKRQR DLAQSQVDEL
430 440 450 460 470 480
RRKLQEEQGP KPSESVSPVV KKCLSFSGTL SPNLEEKAPV RSERTRNTMG RQSMRQSLAA
490 500 510 520 530 540
PFTLMHEIRK LEHLQEQLGD EANRALEVLQ KEVACHRLGN QDAAETIAKL QAEIREMRSI
550 560 570 580 590 600
RPLPKEVEVG SVVAVNKSVS ANLKEEIARL HSQGSTIADL EEQLENVQKS LDKLVMSLPS
610 620 630 640 650 660
NNDQQSNNDT TQKAKHPSKK KKLLPLTSSN SINRQNFLKS PCSPLSTARQ VLDCEVENRA
670 680 690 700 710 720
PDSDDLSCEI QPDETPTKSD GGDVSSKEGT PYRRSSSVNM RKMQKMFQEA AEENVRNIRS
730 740 750 760 770 780
YVTELKERVA KLQYQKQLLV CQVLELEANE AAGYNLEDDE NIHQIPEESP VSWQITFKEQ
790 800 810 820 830 840
RQQIIDLWDV CYVSIIHRSQ FYLLFKGDPA DEIYLEVELR RLTWLQQHLA ELGNATPARV
850 860 870 880 890 900
GNEPTVSLSS SIRALKRERE FLAKRLTTRL TAEERDYLYI KWEVPLEGKQ RRMQFINKLW
910 920 930 940 950
TNPHDAKHVH ESAEIVAKLV GFCEGGNMSR EMFELNFVLP SDRRPWFAGW NQISDLLHI