Q8RXK8
PR
Gene name |
OVA2 |
Protein name |
Isoleucine--tRNA ligase, chloroplastic/mitochondrial |
Names |
Isoleucyl-tRNA synthetase, IleRS, Protein OVULE ABORTION 2 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G49030 |
EC number |
6.1.1.5: Ligases forming aminoacyl-tRNA and related compounds |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8RXK8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8RXK8-F1 | Predicted | AlphaFoldDB |
61 variants for Q8RXK8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_5_19882263_C_A | 10 | G>V | No | 1000Genomes | |
| ENSVATH03395226 | 14 | E>K | No | 1000Genomes | |
| tmp_5_19882249_C_A | 15 | A>S | No | 1000Genomes | |
| ENSVATH14614953 | 17 | A>T | No | 1000Genomes | |
| ENSVATH00721246 | 18 | M>V | No | 1000Genomes | |
| ENSVATH07377389 | 25 | S>Y | No | 1000Genomes | |
| ENSVATH07377376 | 28 | V>D | No | 1000Genomes | |
| ENSVATH14614947 | 46 | F>S | No | 1000Genomes | |
| ENSVATH03395219 | 76 | S>L | No | 1000Genomes | |
| ENSVATH07377372 | 133 | N>K | No | 1000Genomes | |
| tmp_5_19881222_T_C | 144 | N>S | No | 1000Genomes | |
| tmp_5_19881090_C_T | 163 | M>I | No | 1000Genomes | |
| ENSVATH12649011 | 312 | I>V | No | 1000Genomes | |
| ENSVATH12649010 | 320 | K>E | No | 1000Genomes | |
| tmp_5_19879797_T_C,A | 324 | L>F | No | 1000Genomes | |
| ENSVATH07377347 | 350 | A>T | No | 1000Genomes | |
| ENSVATH07377346 | 365 | F>S | No | 1000Genomes | |
| tmp_5_19879481_G_A | 370 | S>L | No | 1000Genomes | |
| tmp_5_19879468_G_C | 374 | S>R | No | 1000Genomes | |
| ENSVATH03395208 | 375 | N>K | No | 1000Genomes | |
| ENSVATH14614923 | 389 | K>R | No | 1000Genomes | |
| ENSVATH14614922 | 400 | P>S | No | 1000Genomes | |
| ENSVATH07377344 | 401 | A>G | No | 1000Genomes | |
| ENSVATH07377343 | 404 | A>V | No | 1000Genomes | |
| ENSVATH12649008 | 416 | F>L | No | 1000Genomes | |
| tmp_5_19879341_G_A | 417 | L>F | No | 1000Genomes | |
| tmp_5_19879191_A_G | 435 | C>R | No | 1000Genomes | |
| tmp_5_19879034_T_A | 487 | E>V | No | 1000Genomes | |
| tmp_5_19878840_T_C | 522 | H>R | No | 1000Genomes | |
| tmp_5_19878787_C_T | 540 | E>K | No | 1000Genomes | |
| tmp_5_19878286_T_A | 615 | K>* | No | 1000Genomes | |
| tmp_5_19878285_T_A | 615 | K>I | No | 1000Genomes | |
| ENSVATH12648980 | 640 | R>L | No | 1000Genomes | |
| ENSVATH14614918 | 641 | D>G | No | 1000Genomes | |
| tmp_5_19877937_T_C | 669 | K>R | No | 1000Genomes | |
| ENSVATH12648976 | 702 | Q>L | No | 1000Genomes | |
| ENSVATH07377328 | 728 | L>I | No | 1000Genomes | |
| tmp_5_19877507_T_C | 746 | D>G | No | 1000Genomes | |
| tmp_5_19877418_G_A | 776 | R>C | No | 1000Genomes | |
| ENSVATH07377327 | 778 | M>I | No | 1000Genomes | |
| tmp_5_19877155_G_C | 818 | L>V | No | 1000Genomes | |
| tmp_5_19877140_T_G | 823 | N>H | No | 1000Genomes | |
| ENSVATH12648943 | 829 | Q>R | No | 1000Genomes | |
| ENSVATH12648942 | 862 | D>E | No | 1000Genomes | |
| tmp_5_19876588_G_A | 882 | S>L | No | 1000Genomes | |
| tmp_5_19876457_T_C | 926 | K>E | No | 1000Genomes | |
| ENSVATH07377315 | 928 | P>T | No | 1000Genomes | |
| tmp_5_19876442_T_G | 931 | N>H | No | 1000Genomes | |
| ENSVATH07377314 | 939 | A>T | No | 1000Genomes | |
| tmp_5_19876413_T_G | 940 | E>D | No | 1000Genomes | |
| ENSVATH03395194 | 942 | V>G | No | 1000Genomes | |
| ENSVATH07377305 | 955 | V>L | No | 1000Genomes | |
| tmp_5_19876023_C_G | 965 | E>D | No | 1000Genomes | |
| tmp_5_19875910_T_C | 1003 | Q>R | No | 1000Genomes | |
| tmp_5_19875336_C_T | 1013 | V>I | No | 1000Genomes | |
| ENSVATH07377301 | 1015 | S>Y | No | 1000Genomes | |
| tmp_5_19875317_T_C | 1019 | K>R | No | 1000Genomes | |
| ENSVATH07377300 | 1029 | G>A | No | 1000Genomes | |
| ENSVATH14614897 | 1067 | P>R | No | 1000Genomes | |
| ENSVATH00721230 | 1071 | G>R | No | 1000Genomes | |
| ENSVATH12648906 | 1078 | V>I | No | 1000Genomes |
No associated diseases with Q8RXK8
5 regional properties for Q8RXK8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Aminoacyl-tRNA synthetase, class I, conserved site | 155 - 166 | IPR001412 |
| domain | Aminoacyl-tRNA synthetase, class Ia | 126 - 768 | IPR002300 |
| domain | Zinc finger, FPG/IleRS-type | 1047 - 1075 | IPR010663 |
| domain | Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding | 814 - 978 | IPR013155 |
| domain | Isoleucyl tRNA synthetase type 1, anticodon-binding domain | 770 - 956 | IPR033708 |
Functions
| Description | ||
|---|---|---|
| EC Number | 6.1.1.5 | Ligases forming aminoacyl-tRNA and related compounds |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| chloroplast | A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. |
| chloroplast stroma | The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| aminoacyl-tRNA editing activity | The hydrolysis of an incorrectly aminoacylated tRNA. |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| isoleucine-tRNA ligase activity | Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H(+). |
| metal ion binding | Binding to a metal ion. |
| tRNA binding | Binding to a transfer RNA. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| isoleucyl-tRNA aminoacylation | The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. The isoleucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a isoleucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. |
| mitochondrial translation | The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code. |
| plant ovule development | The process whose specific outcome is the progression of the ovule over time, from its formation to the mature structure. The ovule is the structure in seed plants enclosing the female gametophyte, and is composed of the nucellus, one or two integuments, and the funiculus; it develops into the seed. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSSFFKSFAG | NPREAAAMAM | VQSSSYRVLS | GKSCSNLRRN | TPLDSFLAKG | RSSVKAFSFL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YVSRFSTEPN | NEFGHSSKRR | SRGPVMAAKK | ASEGEKQEDG | KYKQTVDLPK | TGFGMRANSL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TREPELQKLW | EENQVFKRVS | DNNNGGSFIL | HDGPPYANGD | LHMGHALNKI | LKDIINRYKL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LQNYKVQYVP | GWDCHGLPIE | LKVLQSLDQE | VRKELTPLKL | RAKAAKFAKA | TVKTQMESFK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RFGVWADWNN | PYLTLDPEYE | AAQIEVFGQM | ALKGYIYRGR | KPVHWSPSSR | TALAEAELEY |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PEGHISKSIY | AIFKLVGGAK | TSLLDEFIPN | IYLAVWTTTP | WTMPANAAVA | VNAKLQYSVV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EVQSFSEDES | TVTSNKKKIP | GKVLKNQQKL | FVIVATDLVP | ALEAKWGVKL | SISKTFLGSD |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LENCRYTHPI | DNRDCPVVIG | GDYITTESGT | GLVHTAPGHG | QEDYATGLKY | GLPLVSPVDD |
| 490 | 500 | 510 | 520 | 530 | 540 |
| EGKFTEEAGQ | FRGLSVLGEG | NTAVVSYLDE | NMSLVMEESY | AHKYPYDWRT | KKPTIFRATE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| QWFASVEGFR | TATMDAINNV | KWVPHQAVNR | ISAMTSSRSD | WCISRQRTWG | VPIPAFYHVK |
| 610 | 620 | 630 | 640 | 650 | 660 |
| TKEPLMNEET | INHVKSIISQ | KGSDAWWYMS | VEDLLPEKYR | DKAADYEKGT | DTMDVWFDSG |
| 670 | 680 | 690 | 700 | 710 | 720 |
| SSWAGVLGKR | EGLSFPADVY | LEGTDQHRGW | FQSSLLTSIA | TQGKAPYSAV | ITHGFVLDEK |
| 730 | 740 | 750 | 760 | 770 | 780 |
| GMKMSKSLGN | VVDPRLVIEG | GKNSKDAPAY | GADVMRLWVS | SVDYTGDVLI | GPQILRQMSD |
| 790 | 800 | 810 | 820 | 830 | 840 |
| IYRKLRGTLR | YLLGNLHDWR | VDNAVPYQDL | PIIDQHALFQ | LENVVKNIQE | CYENYQFFKI |
| 850 | 860 | 870 | 880 | 890 | 900 |
| FQIIQRFTIV | DLSNFYFDIA | KDRLYTGGTS | SFTRRSCQTV | LSTHLLSILR | VIAPIVPHLA |
| 910 | 920 | 930 | 940 | 950 | 960 |
| EDVWQNLPFE | YRNEDGSAAE | FVFELKWPTL | NEQWLSFPAE | DVLFWQRLLE | LRTEVNKVLE |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| LARNEKMIGS | SLEAKVYLHT | ADAGMAAKLL | EMSEAKNEAD | TLQRIFITSQ | VEVLSSMEKE |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| MISSVQHTGE | YVEGENKVWI | GVSRAEGSKC | ERCWNYSGQV | GSFSDHPTLC | GRCFSVIVAN |
| 1090 | |||||
| PPEPAVAAVN | SLA |