Q8RXK2
PR
Gene name |
SDN3 (At5g67240, K21H1.20) |
Protein name |
Small RNA degrading nuclease 3 |
Names |
|
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G67240 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8RXK2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8RXK2-F1 | Predicted | AlphaFoldDB |
63 variants for Q8RXK2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_5_26827950_C_A | 12 | L>F | No | 1000Genomes | |
| tmp_5_26827952_A_C | 12 | L>V | No | 1000Genomes | |
| ENSVATH00757027 | 28 | E>D | No | 1000Genomes | |
| tmp_5_26827861_T_C | 42 | K>R | No | 1000Genomes | |
| ENSVATH12963754 | 82 | A>T | No | 1000Genomes | |
| tmp_5_26827632_G_A | 94 | T>I | No | 1000Genomes | |
| tmp_5_26827489_G_T | 112 | D>E | No | 1000Genomes | |
| ENSVATH12963751 | 115 | P>A | No | 1000Genomes | |
| tmp_5_26827474_G_C | 117 | N>K | No | 1000Genomes | |
| tmp_5_26827334_T_C | 134 | K>R | No | 1000Genomes | |
| ENSVATH14652666 | 144 | R>K | No | 1000Genomes | |
| tmp_5_26827216_C_A | 173 | K>N | No | 1000Genomes | |
| ENSVATH07494112 | 179 | F>Y | No | 1000Genomes | |
| ENSVATH03487778 | 209 | A>T | No | 1000Genomes | |
| ENSVATH03487777 | 254 | V>L | No | 1000Genomes | |
| ENSVATH07494109 | 255 | D>A | No | 1000Genomes | |
| ENSVATH14652665 | 255 | D>E | No | 1000Genomes | |
| tmp_5_26826641_G_T | 274 | Q>K | No | 1000Genomes | |
| tmp_5_26826569_C_T | 298 | A>T | No | 1000Genomes | |
| tmp_5_26826547_G_T | 305 | A>D | No | 1000Genomes | |
| ENSVATH12963746 | 317 | A>V | No | 1000Genomes | |
| ENSVATH12963745 | 318 | E>G | No | 1000Genomes | |
| ENSVATH14652662 | 326 | Q>E | No | 1000Genomes | |
| tmp_5_26826286_C_T | 358 | V>I | No | 1000Genomes | |
| ENSVATH03487774 | 361 | P>L | No | 1000Genomes | |
| ENSVATH14652659 | 396 | S>L | No | 1000Genomes | |
| ENSVATH03487771 | 402 | K>N | No | 1000Genomes | |
| ENSVATH07494103 | 403 | A>T | No | 1000Genomes | |
| tmp_5_26825905_C_T | 420 | M>I | No | 1000Genomes | |
| tmp_5_26825858_C_G | 436 | R>P | No | 1000Genomes | |
| ENSVATH07494098 | 443 | S>I | No | 1000Genomes | |
| ENSVATH12963723 | 451 | D>A | No | 1000Genomes | |
| ENSVATH12963722 | 464 | R>K | No | 1000Genomes | |
| ENSVATH03487769 | 466 | A>D | No | 1000Genomes | |
| ENSVATH14652657 | 482 | S>P | No | 1000Genomes | |
| tmp_5_26825709_G_A | 486 | H>Y | No | 1000Genomes | |
| tmp_5_26825691_C_T | 492 | D>N | No | 1000Genomes | |
| ENSVATH07494097 | 496 | D>Y | No | 1000Genomes | |
| tmp_5_26825676_C_T | 497 | V>I | No | 1000Genomes | |
| ENSVATH12963721 | 499 | P>Q | No | 1000Genomes | |
| ENSVATH03487767 | 530 | V>I | No | 1000Genomes | |
| ENSVATH12963720 | 531 | V>I | No | 1000Genomes | |
| tmp_5_26825345_C_A | 547 | S>I | No | 1000Genomes | |
| tmp_5_26825308_C_A | 559 | M>I | No | 1000Genomes | |
| tmp_5_26825288_C_T | 566 | G>D | No | 1000Genomes | |
| tmp_5_26825289_C_T | 566 | G>S | No | 1000Genomes | |
| tmp_5_26825264_G_A | 574 | A>V | No | 1000Genomes | |
| ENSVATH00757024 | 576 | T>A | No | 1000Genomes | |
| ENSVATH03487764 | 590 | D>E | No | 1000Genomes | |
| tmp_5_26825207_T_A | 593 | E>V | No | 1000Genomes | |
| tmp_5_26825187_C_T | 600 | A>T | No | 1000Genomes | |
| tmp_5_26825135_A_G | 617 | L>P | No | 1000Genomes | |
| ENSVATH14652654 | 625 | K>N | No | 1000Genomes | |
| tmp_5_26825099_G_A | 629 | T>I | No | 1000Genomes | |
| tmp_5_26824981_G_A | 638 | P>S | No | 1000Genomes | |
| ENSVATH07494085 | 679 | K>R | No | 1000Genomes | |
| ENSVATH07494084 | 691 | A>T | No | 1000Genomes | |
| tmp_5_26824729_A_G | 692 | C>R | No | 1000Genomes | |
| tmp_5_26824682_T_A | 707 | K>N | No | 1000Genomes | |
| tmp_5_26824557_T_A | 749 | K>M | No | 1000Genomes | |
| tmp_5_26824464_G_A | 780 | S>F | No | 1000Genomes | |
| tmp_5_26824462_G_A | 781 | R>W | No | 1000Genomes | |
| tmp_5_26824455_C_CA | 783 | S>L | No | 1000Genomes |
No associated diseases with Q8RXK2
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| mediator complex | A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| exonuclease activity | Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A3KPE8 | SDN1 | Small RNA degrading nuclease 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEHKLATAEK | KLLVDLVKLV | QKRGLEGENG | GWKEFLNVYD | KKLGSSLSDP | ARRSNDVLVA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FLLTFKKKED | LQLIARVMQC | GANRELIEKF | KQETPDKETP | EQRLVRLTIT | HDDYPGNYTF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PSYAEDWYVT | ELGKKKSKVI | KSTRMLSIDC | EMVTCEDGSQ | ALVRVGAVDR | DLKVVLDKFV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KPDKPVIDYK | TDITGVTAED | LERATLSVAD | IQKKLRRFLS | VGTILVGHGL | HNDLQVLRID |
| 250 | 260 | 270 | 280 | 290 | 300 |
| HARVIDTSYV | FEFVDAPKTQ | RPSLNNLCKS | VLGQEVRMDG | AAHNCVHDAA | AAMKLVLAAV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EKGAATLIQP | TEEMMVAEKR | RQEARQEAGK | AQLFLHKIPH | DVPSEELHGV | LSGNFTLVVK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PPKTGGYSTA | VVDFSSPEEA | NEAFENVEGD | VAKDKSGLPQ | KKAVLKLSSG | LAVSLFVRKM |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VQDDSPCEIS | TSERARAEEN | NVSSKRQKTE | DETEETKEAT | VNQREADKTK | LFLHKIPHDV |
| 490 | 500 | 510 | 520 | 530 | 540 |
| PSQELHGVLN | GDFTLDVKPP | KRKGGYYNAV | VDFNSPEEAN | EAFENVEGDV | VKDKTGLPQK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| MVVFKLSSGS | GVSLYVRKMV | HDDSPGEIST | TKRARTEESN | MSSKRQKTED | ESEETKEANA |
| 610 | 620 | 630 | 640 | 650 | 660 |
| KQREADKTKL | LLHKIPLNVP | SQELKVVITG | QFTLEVMPPK | RKGRYYNAVV | TFNSPEEANK |
| 670 | 680 | 690 | 700 | 710 | 720 |
| AFEKVKGEAV | KEKGGLAQKM | VAFKLSSGSG | ACLYVRKMVQ | DESEETKEAN | ANHCEDDHLK |
| 730 | 740 | 750 | 760 | 770 | 780 |
| EMEELKEKLK | AMEFAISCEG | HSKEIEELKQ | KLNAKEHQIQ | AQDKIIANLK | MKLEKKQSKS |
| RS |