Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q8RWY4

Entry ID Method Resolution Chain Position Source
AF-Q8RWY4-F1 Predicted AlphaFoldDB

103 variants for Q8RWY4

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH00120536 9 S>C No 1000Genomes
ENSVATH00120537 19 F>C No 1000Genomes
ENSVATH13722823 20 A>P No 1000Genomes
tmp_1_23959914_C_A 32 S>Y No 1000Genomes
ENSVATH01462165 45 T>A No 1000Genomes
tmp_1_23959959_G_C 47 G>A No 1000Genomes
ENSVATH00120538 52 E>D No 1000Genomes
ENSVATH14409994 53 L>I No 1000Genomes
ENSVATH13722824 55 S>P No 1000Genomes
ENSVATH05058490 60 P>S No 1000Genomes
tmp_1_23960004_G_T 62 R>L No 1000Genomes
ENSVATH14410015 87 S>F No 1000Genomes
ENSVATH13722827 88 P>L No 1000Genomes
ENSVATH01462166 92 I>V No 1000Genomes
ENSVATH05058497 96 E>D No 1000Genomes
tmp_1_23960376_G_A 132 V>I No 1000Genomes
ENSVATH05058505 232 V>L No 1000Genomes
ENSVATH00120547 272 T>P No 1000Genomes
tmp_1_23960888_C_G 272 T>S No 1000Genomes
ENSVATH14410016 312 R>H No 1000Genomes
ENSVATH13722832 326 S>L No 1000Genomes
tmp_1_23961253_A_G 351 H>R No 1000Genomes
tmp_1_23961327_C_G 376 Q>E No 1000Genomes
tmp_1_23961364_G_A 388 R>Q No 1000Genomes
ENSVATH01462170 393 D>N No 1000Genomes
ENSVATH14410017 394 Y>H No 1000Genomes
tmp_1_23961447_A_T 416 T>S No 1000Genomes
tmp_1_23961450_T_C 417 Y>H No 1000Genomes
ENSVATH14410018 455 S>L No 1000Genomes
ENSVATH13722833 461 S>Y No 1000Genomes
tmp_1_23961630_G_C 477 A>P No 1000Genomes
ENSVATH01462171 478 S>L No 1000Genomes
ENSVATH05058535 481 G>R No 1000Genomes
ENSVATH00120557 482 M>I No 1000Genomes
ENSVATH13722834 491 R>W No 1000Genomes
ENSVATH05058537 492 I>V No 1000Genomes
ENSVATH05058538 497 Q>P No 1000Genomes
ENSVATH14410019 501 D>E No 1000Genomes
tmp_1_23961728_A_C 509 E>D No 1000Genomes
ENSVATH13722835 509 E>K No 1000Genomes
ENSVATH05058539 512 V>L No 1000Genomes
ENSVATH05058539 512 V>M No 1000Genomes
ENSVATH13722836 515 N>K No 1000Genomes
tmp_1_23961747_T_C 516 S>P No 1000Genomes
ENSVATH05058540 518 F>L No 1000Genomes
ENSVATH05058541 523 E>D No 1000Genomes
tmp_1_23961775_A_C 525 D>A No 1000Genomes
ENSVATH05058542 527 G>R No 1000Genomes
ENSVATH05058543 528 V>F No 1000Genomes
ENSVATH05058544 530 R>K No 1000Genomes
ENSVATH01462173 531 F>V No 1000Genomes
ENSVATH05058545 534 L>V No 1000Genomes
ENSVATH13722837 537 I>T No 1000Genomes
tmp_1_23961813_C_T 538 P>S No 1000Genomes
tmp_1_23961819_G_A 540 A>T No 1000Genomes
ENSVATH05058547 540 A>V No 1000Genomes
ENSVATH14410020 546 S>P No 1000Genomes
ENSVATH05058548 567 A>S No 1000Genomes
tmp_1_23962050_G_A 592 G>R No 1000Genomes
ENSVATH13722840 620 G>D No 1000Genomes
ENSVATH14410022 634 P>A No 1000Genomes
tmp_1_23962187_C_G 637 H>Q No 1000Genomes
tmp_1_23962189_A_G 638 Q>R No 1000Genomes
ENSVATH05058563 639 I>M No 1000Genomes
ENSVATH05058565 641 P>L No 1000Genomes
ENSVATH05058564 641 P>S No 1000Genomes
ENSVATH05058566 643 D>A No 1000Genomes
ENSVATH05058567 643 D>E No 1000Genomes
ENSVATH05058568 644 I>N No 1000Genomes
ENSVATH05058569 647 A>P No 1000Genomes
tmp_1_23962227_C_T 651 P>S No 1000Genomes
tmp_1_23962231_C_T 652 P>L No 1000Genomes
tmp_1_23962233_A_T 653 T>S No 1000Genomes
tmp_1_23962245_C_T 657 P>S No 1000Genomes
ENSVATH05058572 662 Q>K No 1000Genomes
tmp_1_23962272_A_C 666 I>L No 1000Genomes
ENSVATH05058573 669 R>K No 1000Genomes
tmp_1_23962293_G_A 673 D>N No 1000Genomes
tmp_1_23962311_A_G 679 T>A No 1000Genomes
ENSVATH05058574 681 R>C No 1000Genomes
ENSVATH05058575 681 R>H No 1000Genomes
ENSVATH01462175 682 A>G No 1000Genomes
ENSVATH05058579 687 N>D No 1000Genomes
ENSVATH05058580 687 N>S No 1000Genomes
ENSVATH13722844 688 P>L No 1000Genomes
ENSVATH05058581 690 C>S No 1000Genomes
tmp_1_23962447_C_T 693 R>C No 1000Genomes
tmp_1_23962448_G_T 693 R>L No 1000Genomes
tmp_1_23962457_T_A 696 L>H No 1000Genomes
ENSVATH05058582 700 N>K No 1000Genomes
ENSVATH05058583 707 V>A No 1000Genomes
tmp_1_23962532_A_G 721 N>S No 1000Genomes
tmp_1_23962537_T_A 723 W>R No 1000Genomes
ENSVATH05058585 727 T>S No 1000Genomes
tmp_1_23962561_A_T 731 T>S No 1000Genomes
tmp_1_23962574_C_T 735 T>I No 1000Genomes
ENSVATH05058588 757 I>L No 1000Genomes
ENSVATH14410046 758 S>L No 1000Genomes
tmp_1_23962654_G_A 762 V>I No 1000Genomes
ENSVATH05058590 765 T>A No 1000Genomes
tmp_1_23962709_C_A 780 A>E No 1000Genomes
ENSVATH13722847 825 F>L No 1000Genomes
ENSVATH13722848 840 C>S No 1000Genomes

No associated diseases with Q8RWY4

3 regional properties for Q8RWY4

Type Name Position InterPro Accession
domain PB1 domain 741 - 823 IPR000270
domain RWP-RK domain 539 - 624 IPR003035
domain Protein NLP, PB1 domain 742 - 822 IPR034891

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
DNA-binding transcription factor activity A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
transcription cis-regulatory region binding Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MELDDLDLSG SWPLDQITFA SNFKSPVIFS SSEQPFSPLW SFSETSGDVG GELYSAAVAP
70 80 90 100 110 120
TRFTDYSVLL ASSESETTTK ENNQVPSPSW GIMPLENPDS YCAIKAKMTQ ALRYFKESTG
130 140 150 160 170 180
QQHVLAQVWA PVKNRGRYVL TTSGQPFVLG PNSNGLNQYR MVSLTYMFSL DGERDGELGL
190 200 210 220 230 240
PGRVFRKKLP EWTPNVQYYS SKEFSRLGHA LHYNVQGTLA LPVFEPSRQL CVGVVELIMT
250 260 270 280 290 300
SPKINYAPEV EKVCKALEAV NLKTSEILNH ETTQICNEGR QNALAEILEI LTVVCETYKL
310 320 330 340 350 360
PLAQTWVPCR HRSVLAFGGG FKKSCSSFDG SCMGKVCMST SDLAVYVVDA HVWGFRDACA
370 380 390 400 410 420
EHHLQKGQGV AGRAFQSGNL CFCRDVTRFC KTDYPLVHYA RMFKLTSCFA VCLKSTYTGD
430 440 450 460 470 480
DEYVLEFFLP PAITDKSEQD CLLGSLLQTM KQHYSSLKVV SETELCENNM SLEVVEASED
490 500 510 520 530 540
GMVYSKLEPI RIHHPAQISK DYLELNAPEQ KVSLNSDFME NNEVDDGVER FQTLDPIPEA
550 560 570 580 590 600
KTVKKSERKR GKTEKTISLE VLQQYFAGSL KDAAKSLGVC PTTMKRICRQ HGISRWPSRK
610 620 630 640 650 660
INKVNRSLTR LKHVIDSVQG ADGSLNLTSL SPRPWPHQIP PIDIQLAKNC PPTSTSPLSN
670 680 690 700 710 720
LQDVKIENRD AEDSAGSSTS RASCKVNPIC ETRFRLPTHN QEPSRQVALD DSDSSSKNMT
730 740 750 760 770 780
NFWAHLTCQD TASPTILQHK LVSIKATYRE DIIRFKISPE SVSITELKQQ VAKRLKLETA
790 800 810 820 830 840
AFELKYLDDD REWVSVSCDA DLSECLDTSA AKANTLRLSV HDVTFNFGSS CESSEETMMC
L