Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
4 structures for Q8RN04
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1LFK | X-ray | 170 A | A | 1-398 | PDB |
| 1LG9 | X-ray | 200 A | A | 1-398 | PDB |
| 1LGF | X-ray | 220 A | A | 1-398 | PDB |
| AF-Q8RN04-F1 | Predicted | AlphaFoldDB |
No variants for Q8RN04
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q8RN04 | |||||
No associated diseases with Q8RN04
1 regional properties for Q8RN04
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Cytochrome P450, conserved site | 340 - 349 | IPR017972 |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| heme binding | Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. |
| iron ion binding | Binding to an iron (Fe) ion. |
| monooxygenase activity | Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| vancomycin biosynthetic process | The chemical reactions and pathways leading to the formation of vancomycin, (3S,6R,7R,11R,23S,26S,30aS,36R,38aR)-44-[2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyloxy]-3-(carbamoylmethyl)-10,19-dichloro-2,3,4,5,6,7,23,25,26,36,37,38,38a-tetradecahydro-7,22,28,30,32-pentahydroxy-6-(N-methyl-D-leucyl)-2,5,24,38,39-pentaoxo-1H,22H-23,36-(epiminomethano)-8,11:18,21-dietheno-13,16:31,35-di(metheno) |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSEDDPRPLH | IRRQGLDPAD | ELLAAGALTR | VTIGSGADAE | THWMATAHAV | VRQVMGDHQQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FSTRRRWDPR | DEIGGKGIFR | PRELVGNLMD | YDPPEHTRLR | RKLTPGFTLR | KMQRMAPYIE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QIVNDRLDEM | ERAGSPADLI | AFVADKVPGA | VLCELVGVPR | DDRDMFMKLC | HGHLDASLSQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KRRAALGDKF | SRYLLAMIAR | ERKEPGEGMI | GAVVAEYGDD | ATDEELRGFC | VQVMLAGDDN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ISGMIGLGVL | AMLRHPEQID | AFRGDEQSAQ | RAVDELIRYL | TVPYSPTPRI | AREDLTLAGQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EIKKGDSVIC | SLPAANRDPA | LAPDVDRLDV | TREPIPHVAF | GHGVHHCLGA | ALARLELRTV |
| 370 | 380 | 390 | |||
| FTELWRRFPA | LRLADPAQDT | EFRLTTPAYG | LTELMVAW |