Q8RI94

PR
Gene name
ligA
Protein name
DNA ligase
Names
Polydeoxyribonucleotide synthase [NAD(+)]
Species
Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355)
KEGG Pathway
fnu:FN1717
EC number
6.5.1.2: Forming phosphoric ester bonds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-51 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8RI94

Entry ID Method Resolution Chain Position Source
AF-Q8RI94-F1 Predicted AlphaFoldDB

No variants for Q8RI94

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8RI94

No associated diseases with Q8RI94

10 regional properties for Q8RI94

Type Name Position InterPro Accession
domain BRCT domain 615 - 695 IPR001357
domain Helix-hairpin-helix DNA-binding motif, class 1 465 - 484 IPR003583-1
domain Helix-hairpin-helix DNA-binding motif, class 1 501 - 520 IPR003583-2
domain Helix-hairpin-helix DNA-binding motif, class 1 565 - 584 IPR003583-3
domain Zinc-finger, NAD-dependent DNA ligase C4-type 428 - 453 IPR004149
domain NAD-dependent DNA ligase, OB-fold 342 - 418 IPR004150
domain NAD-dependent DNA ligase, adenylation 29 - 337 IPR013839
domain NAD-dependent DNA ligase, N-terminal 26 - 467 IPR013840
active_site NAD-dependent DNA ligase, active site 139 - 168 IPR018239
domain DisA/LigA, helix-hairpin-helix motif 532 - 594 IPR041663

Functions

Description
EC Number 6.5.1.2 Forming phosphoric ester bonds
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

3 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA ligase (NAD+) activity Catalysis of the reaction: NAD+ + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + nicotinamide nucleotide + deoxyribonucleotide(n+m).
metal ion binding Binding to a metal ion.

2 GO annotations of biological process

Name Definition
base-excision repair, DNA ligation The ligation by DNA ligase of DNA strands. Ligation occurs after polymerase action to fill the gap left by the action of endonucleases during base-excision repair.
DNA replication The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEIKKRIEEL KNNQTGLTFY SSQELNDLEK IVKLREDLNK YRDSYYNDNK SLISDYEFDI
70 80 90 100 110 120
LLKELESLEE KYPQYKEISS PTTSVGASLK ENKFKKVEHL HPMLSLANSY NIGEIVEFIE
130 140 150 160 170 180
RIKKKIPKEQ ELKYCLEVKL DGLSISLTYR QGKLVRAVTR GDGFIGEDVT ENILEIASIV
190 200 210 220 230 240
KTLPQAIDME IRGEVVLPLA SFEKLNNERL EKGEELFANP RNAASGTLRQ LDSKIVKDRG
250 260 270 280 290 300
LDAYFYFLVE ADKLGLKSHS ESIKFLESMG IKTTGIFELL ETSKDIEKRI NYWEKERESL
310 320 330 340 350 360
PYETDGLVIK VDEINLWDEI GYTSKTPRWA IAYKFPAHQV STVLNDVTWQ VGRTGKLTPV
370 380 390 400 410 420
AELQEVELSG SKVKRASLHN ISEIQRKDIR IGDRVFIEKA AEIIPQVVKA IKEERTGNEK
430 440 450 460 470 480
VIEEPTCCPI CNHKLEREEG LVDIKCINEE CPAKVQGEIE YFVSRDALNI MGLGSKIVEK
490 500 510 520 530 540
FIDLGYIKTV VDIFDLKNHR EALENIDKMG KKSIENLLNS IEESKNRDYD KILYALGIAE
550 560 570 580 590 600
IGKVTSKILA KASKNIDKLM AMTFEDLTSI EGIGEIAANE IIAFFTKEKN QKIIQGLKEK
610 620 630 640 650 660
GLKFEIKESE ASVQNVNPNF VGKNFLFTGT LKHFTREQIK EEIEKLGGKN LSSVSKNLDY
670 680 690
LIVGEKAGSK LKKAQEIPTI KILTEEEFIE LKDKFD