Q8RHQ8
Gene name |
clpB (FN1941) |
Protein name |
Chaperone protein ClpB |
Names |
|
Species |
Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355) |
KEGG Pathway |
fnu:FN1941 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8RHQ8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8RHQ8-F1 | Predicted | AlphaFoldDB |
No variants for Q8RHQ8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q8RHQ8 | |||||
No associated diseases with Q8RHQ8
9 regional properties for Q8RHQ8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | AAA+ ATPase domain | 194 - 339 | IPR003593-1 |
| domain | AAA+ ATPase domain | 599 - 759 | IPR003593-2 |
| domain | ATPase, AAA-type, core | 199 - 316 | IPR003959-1 |
| domain | ATPase, AAA-type, core | 598 - 760 | IPR003959-2 |
| domain | Clp, repeat (R) domain | 1 - 142 | IPR004176 |
| conserved_site | ClpA/B, conserved site 1 | 290 - 302 | IPR018368 |
| domain | Clp ATPase, C-terminal | 766 - 855 | IPR019489 |
| conserved_site | ClpA/B, conserved site 2 | 633 - 651 | IPR028299 |
| domain | ClpA/ClpB, AAA lid domain | 338 - 438 | IPR041546 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to heat | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. |
| protein refolding | The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNPNQFTENT | ISAINLAVDI | SKGNMQQSIK | PEALALGLLM | QNNGLIPRVI | EKMGLNLQYI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ISELEKEMNN | YPKVEVKVSN | ENISLDQKTN | SILNRAEKIM | NEMEDSFLSV | EHIFKAMIEE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| MPIFKRFGIS | LEKYMEVLMN | IRGNRKVDNQ | NPEATYEVLE | KYAKDLVELA | REGKIDPIIG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RDSEIRRAIQ | IISRRTKNDP | ILIGEPGVGK | TAIVEGLAQR | ILNGDVPESL | KNKKIFSLDM |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GALVAGAKYK | GEFEERMKGV | LKEVEESNGN | IILFIDEIHT | IVGAGKGEGS | LDAGNMLKPM |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LARGELRVIG | ATTIDEYRKY | IEKDPALERR | FQTILVNEPN | VDDTISILRG | LKDKFETYHG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VRITDTAIVE | AATLSQRYIS | DRKLPDKAID | LIDEAAAMIR | TEIDSMPEEL | DQLTRKALQL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| EIEIKALEKE | TDDASKERLK | VIEKELAELN | EEKKVLTSKW | ELEKEDISKI | KNIKREIENV |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KLEMEKAERE | YDLTKLSELK | YGKLATLEKE | LQEQQNKVDK | DGKENSLLKQ | EVTADEIADI |
| 550 | 560 | 570 | 580 | 590 | 600 |
| VSRWTGIPVS | KLTETKKEKM | LHLEDHIKER | VKGQDEAIKS | VADTMLRSVA | GLKDPNRPMG |
| 610 | 620 | 630 | 640 | 650 | 660 |
| SFIFLGPTGV | GKTYLAKTLA | YNLFDSEDNV | VRIDMSEYMD | KFSVTRLIGA | PPGYVGYEEG |
| 670 | 680 | 690 | 700 | 710 | 720 |
| GQLTEAIRTK | PYSVILFDEI | EKAHPDVFNV | LLQVLDDGRL | TDGQGRIVDF | KNTLIIMTSN |
| 730 | 740 | 750 | 760 | 770 | 780 |
| IGSHFILEDP | NLSEDTREKV | ADELKARFKP | EFLNRIDEII | TFKALDLPAI | KEIVKLSLKD |
| 790 | 800 | 810 | 820 | 830 | 840 |
| LENKLKPKHI | TLEFSDKMVD | YLANNAYDPH | YGARPLRRYI | QREIETSLAK | KILANEVHEK |
| 850 | |||||
| SNVLIDLDNN | HIVFKEV |