Q8RGW9
Gene name |
disA |
Protein name |
DNA integrity scanning protein DisA |
Names |
Cyclic di-AMP synthase, c-di-AMP synthase, Diadenylate cyclase |
Species |
Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355) |
KEGG Pathway |
fnu:FN0158 |
EC number |
2.7.7.85: Nucleotidyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8RGW9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8RGW9-F1 | Predicted | AlphaFoldDB |
No variants for Q8RGW9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q8RGW9 | |||||
No associated diseases with Q8RGW9
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.7.85 | Nucleotidyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| adenylate cyclase activity | Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate. |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| diadenylate cyclase activity | Catalysis of the reaction: 2 ATP = 3',3'-c-di-AMP + 2 diphosphate. |
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA repair | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. |
| second-messenger-mediated signaling | Any intracellular signal transduction in which the signal is passed on within the cell via a second messenger; a small molecule or ion that can be quickly generated or released from intracellular stores, and can diffuse within the cell. Second-messenger signaling includes production or release of the second messenger, and effectors downstream of the second messenger that further transmit the signal within the cell. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTKQDLMDII | VKVAPGSPLR | EGVDYILDAG | IGALIIIGYD | DEVEKVRDGG | FLIDCDYTPE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RIFELSKMDG | AIILNDDCSK | ILYANVHVQP | DNSYSTTESG | TRHRTAERAA | KHLKREVVAI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SERKKNVTLY | KGNLKYRLKN | FDELNIEVGQ | VLKTLESYRH | VLNRSLDSLT | ILELDDLVTV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LDVANTLQRF | EMVRRISEEI | TRYLLELGSR | GRLVNMQVSE | LIWDLDEEEE | SFLKDYIDDE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TDTDSVRRYL | HSLSDSELLE | VENVVVALGY | SKSSSVFDNK | IAAKGYRVLE | KISKLTKKDV |
| 310 | 320 | 330 | 340 | ||
| EKIVNTYKDI | SEIQEVTDED | FSAIKISKFK | IKALRAGINR | LKFTIEMQR |