Q8RFS6

PR
Gene name
thrS
Protein name
Threonine--tRNA ligase
Names
Threonyl-tRNA synthetase, ThrRS
Species
Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355)
KEGG Pathway
fnu:FN0611
EC number
6.1.1.3: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-44 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8RFS6

Entry ID Method Resolution Chain Position Source
AF-Q8RFS6-F1 Predicted AlphaFoldDB

No variants for Q8RFS6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8RFS6

No associated diseases with Q8RFS6

7 regional properties for Q8RFS6

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 300 - 510 IPR002314
domain TGS 1 - 42 IPR004095
domain Anticodon-binding 522 - 611 IPR004154
domain Aminoacyl-tRNA synthetase, class II 249 - 515 IPR006195
domain Threonyl/alanyl tRNA synthetase, SAD 151 - 200 IPR012947
domain Threonine-tRNA ligase catalytic core domain 224 - 520 IPR033728
domain Threonine-tRNA ligase, class IIa, anticodon-binding domain 520 - 606 IPR047246

Functions

Description
EC Number 6.1.1.3 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
threonine-tRNA ligase activity Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).
tRNA binding Binding to a transfer RNA.

1 GO annotations of biological process

Name Definition
threonyl-tRNA aminoacylation The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. The threonyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a threonine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MFEIAKGISN SLAKKSVGAK VDGKNVDMSY ILDHDAEVEF IDIDSPEGED IVRHSTAHLM
70 80 90 100 110 120
AQAVLRLYPD TKVTIGPVIE NGFYYDFDPV EQFTEEDLEK IEAEMKRIVK ENIKLEKYVL
130 140 150 160 170 180
PRDEAIEYFR DVDKNKYKVE VVEGIPQGEQ VSFYKQGDFT DLCRGTHVPS TGYLKAFKLR
190 200 210 220 230 240
TVAGAYWRGN SKNKMLQRIY GYSFSNEERL KHHLKLMEEA EKRDHRKLGK ELELFFLSEY
250 260 270 280 290 300
GPGFPFFLPK GMIVRNVLID LWRREHEKAG YQQLETPIML NKELWEISGH WFNYRENMYT
310 320 330 340 350 360
SEIDELEFAI KPMNCPGGVL AFKHQLHSYK DLPARLAELG RVHRHEFSGA LHGLMRVRSF
370 380 390 400 410 420
TQDDSHIFMT PDQVQDEIIG VVNLIDKFYS KLFGFEYEIE LSTKPEKAIG SQEIWDMAEA
430 440 450 460 470 480
ALAGALDKLG RKYKINPGDG AFYGPKLDFK IKDAIGRMWQ CGTIQLDFNL PERFDVTYIG
490 500 510 520 530 540
EDGEKHRPVM LHRVIYGSIE RFIGILIEHY AGAFPMWLAP VQVKVLTLND ECIPYAKEIM
550 560 570 580 590 600
NKLEELGIRA ELDDRNETIG YKIREANGKY KIPMQLIIGK NEVENKEVNI RRFGSKDQFS
610
KLLDEFYTYV VDEATIKFDK