Q8RCT6

PR
Gene name
leuS
Protein name
Leucine--tRNA ligase
Names
Leucyl-tRNA synthetase, LeuRS
Species
Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis)
KEGG Pathway
tte:TTE0324
EC number
6.1.1.4: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

252-326 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8RCT6

Entry ID Method Resolution Chain Position Source
AF-Q8RCT6-F1 Predicted AlphaFoldDB

No variants for Q8RCT6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8RCT6

No associated diseases with Q8RCT6

4 regional properties for Q8RCT6

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class Ia 416 - 606 IPR002300
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 665 - 780 IPR013155
domain Methionyl/Leucyl tRNA synthetase 41 - 185 IPR015413
domain Leucyl-tRNA synthetase, editing domain 221 - 402 IPR025709

Functions

Description
EC Number 6.1.1.4 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
leucine-tRNA ligase activity Catalysis of the reaction: L-leucine + ATP + tRNA(Leu) = AMP + diphosphate + 2 H(+) + Leu-tRNA(Leu).

1 GO annotations of biological process

Name Definition
leucyl-tRNA aminoacylation The process of coupling leucine to leucyl-tRNA, catalyzed by leucyl-tRNA synthetase. The leucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a leucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEDMAYSVEI DRKWQKIWEE TKLYKFNPEN VDKKLYCLEM FPYPSGAKLH IGHWYNYGPT
70 80 90 100 110 120
DSWARMKRMQ GYEVFHPMGF DAFGLPAENY AIKTGIHPYD STMENIRTME RQLREMGVTF
130 140 150 160 170 180
DWDYEIITCL PEYYKWTQWI FLKLYEAGLA YRKKAPVNWC PSCQTVLANE QVIDGKCERC
190 200 210 220 230 240
GTEVTKKELT QWFFKITAYA EELLEKLDDL DWPEKTKMMQ RNWIGKSEGA EIEFKIDGKD
250 260 270 280 290 300
LSFRVFTTRA DTLFGATYVV LAPEHELVDL ITTEEYKEAV EEYKEYAKKQ SEIERLSTEK
310 320 330 340 350 360
EKTGVFTGAY AIHPLTGEKL PIWIADYVLV TYGTGCVMGV PGHDERDYEF ATKYNLPIKR
370 380 390 400 410 420
VIKGVGDVDD SLPFVEYGIL VNSEEFTGMT SEEARVKIVE KLKAEGKAEF KVNYRMRDWL
430 440 450 460 470 480
VSRQRYWGAP IPIIHCERCG IVPVPEEDLP VLLPYDVEFE PTGESPLKKH AGFMNVTCPK
490 500 510 520 530 540
CGGPALRDPD TLDTFVDSSW YYLRYPDNKN DKEPFNKEWI NKMLPVDKYV GGAEHATMHL
550 560 570 580 590 600
LYSRFITKVL RDLGYLNFDE PFLSLVHQGT ILGPDGSRMS KSRGNVISPD DYIKQYGSDV
610 620 630 640 650 660
FRLYLMFGFS YSEGGPWSDE GIKAIARFVN RVERFIEKFI ETRQNPGKTK EEMEDAEKEL
670 680 690 700 710 720
NYVRHYTIKH VTLDADKFEF NTAIARIMEL VNALYKYENE VEVKNMKFYE DVVRDFVKIL
730 740 750 760 770 780
APFAPHFSEE MWERLGYEYS VFNQKWPEWD EKALERDMIE IAIQVNGKVR SKAQVPSNAT
790 800 810
DEELKQIALS DERVKSYLDG KEIKKVIIVK NRLVNIVVN