Q8RBN5

PR
Gene name
valS
Protein name
Valine--tRNA ligase
Names
Valyl-tRNA synthetase, ValRS
Species
Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis)
KEGG Pathway
tte:TTE0781
EC number
6.1.1.9: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

760-879 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8RBN5

Entry ID Method Resolution Chain Position Source
AF-Q8RBN5-F1 Predicted AlphaFoldDB

No variants for Q8RBN5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8RBN5

No associated diseases with Q8RBN5

5 regional properties for Q8RBN5

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 45 - 56 IPR001412
domain Aminoacyl-tRNA synthetase, class Ia 17 - 564 IPR002300
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 606 - 754 IPR013155
domain Valyl-tRNA synthetase, tRNA-binding arm 813 - 877 IPR019499
domain Valyl tRNA synthetase, anticodon-binding domain 564 - 697 IPR033705

Functions

Description
EC Number 6.1.1.9 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
valine-tRNA ligase activity Catalysis of the reaction: L-valine + ATP + tRNA(Val) = L-valyl-tRNA(Val) + AMP + diphosphate + 2 H(+).

1 GO annotations of biological process

Name Definition
valyl-tRNA aminoacylation The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. The valyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a valine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKDIAKTYNP KEFEDRIYSF WMEKGFFTPE IDPEKKPFTI VIPPPNVTGE LHMGHALDNT
70 80 90 100 110 120
LQDILIRWRR MQGYAALWIP GTDHASIATE IKVLDKIREE TGKTKKDLTR EEFLEKAWEW
130 140 150 160 170 180
KDKYENRILS QLKKLGSSCD WTRTAFTMDE KRSKAVREVF VSLYEKGLIY KGNRIINWCP
190 200 210 220 230 240
SCNTALSDAE VEHKEHKGHL WYIKYPVKGE EDYVVIATTR PETMLGDVAV AVHPEDERYR
250 260 270 280 290 300
HLIGKTLILP LVGREIPVIA DEYVDPSFGT GAVKVTPAHD PNDFEIGVRH NLPFVNIMNE
310 320 330 340 350 360
NATINENGGK YEGLDRYEAR EKIVKDLEEQ GLLLKVEEHV HNVGHCYRCD TVVEPLLSEQ
370 380 390 400 410 420
WFVKMEPLAK PALQVVKEGK IKFVPERFEK IYTNWLENIK DWCISRQLWW GHRIPAWYCE
430 440 450 460 470 480
DCGHVTVSRE DPVKCEVCGS TNIHQDENVL DTWFSSALWP FSTMGWPEET EDLKYFYPTD
490 500 510 520 530 540
VLVTGYDIIF FWVARMIFMS LEFMKEIPFK YVLIHGLVRD ALGRKMSKSL GNGIDPLEVI
550 560 570 580 590 600
EKYGADTLRF TLVIGNAPGN DMRFSWEKVE HSRNFANKLW NASRYVLLNL DENDTNLYLD
610 620 630 640 650 660
NLALADKWIL TRYNNIVKEI TDNLEKFELG VAASKLYDFV WSEFCDWYIE LSKPVLYSDN
670 680 690 700 710 720
EEAKKVTKSV LRYVLDNTLR LLHPFMPFIT EEIWQNLPHE GESIMVAEWP KYREDLNFEE
730 740 750 760 770 780
DAKKAEIIME AIRAIRNIRA EANVSPSKKA KVIIAVEKEE HEKIFESGKN YIMKLAGASE
790 800 810 820 830 840
VAIERNRDNI PQKAMSAAIS AGLIAVPLEE LIDLEEEIKR LEEEREKVLK EIERAQSLLN
850 860 870
NENFVKKAPE KVVNAEREKL EKYTAMLKNI EERLSLLNS