Q8RAH4

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis)
KEGG Pathway
tte:TTE1248
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

386-470 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8RAH4

Entry ID Method Resolution Chain Position Source
AF-Q8RAH4-F1 Predicted AlphaFoldDB

No variants for Q8RAH4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8RAH4

No associated diseases with Q8RAH4

4 regional properties for Q8RAH4

Type Name Position InterPro Accession
domain DHHA1 domain 733 - 872 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 653 - 696 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 8 - 554 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 4 - 709 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEKLGMNEIR EKFLSFFESK GHLRLPSFSL VPKNDKSLLL INSGMAPLKP YFTGKETPPS
70 80 90 100 110 120
RRVTTCQRCI RTPDIERVGK TARHATFFEM LGNFSFGDYF KKEAIPWAWE FVAEVLKLPV
130 140 150 160 170 180
DRLWVTIYEE DDEAFEIWNK IVGLPPERIV RMGKEDNFWE IGTGPCGPCS EIYFDRGEEK
190 200 210 220 230 240
GCGKPDCGIG CDDCDRYVEF WNLVFTQFNK DEQGNYHRLP NPNIDTGMGL ERIAAIMQGV
250 260 270 280 290 300
DTIFDVDVIR GIRDFISDLA EVEYGKDADK DVSIRVITDH IRGITFMISD GILPSNEGRG
310 320 330 340 350 360
YVLRRLLRRA ARHGKLLGLN DAFLYKVVDS VVENYGGAYP EIIERKDYIK KIIKLEEERF
370 380 390 400 410 420
KETVDQGLAI LQDYINELKA QGKTVLEGAK AFKLYDTYGF PLDLTKEILQ ESGITIDEEG
430 440 450 460 470 480
YKEELEKQRV RARSSRKEDN SLWEQDIYST LGDISTKFVG YEVYESEAKV LAIVKDNEVV
490 500 510 520 530 540
EQAEAGDDVS IILDVTPFYA ESGGQVGDSG VIEEEDTLIK VNDCKKVGNK FIHIGTVERG
550 560 570 580 590 600
LISVGDKVVA KIDVSKRKGA ARNHTATHLL HKALKEVLGD HVNQSGSLVA YDRLRFDFSH
610 620 630 640 650 660
YQAVSKEELK KIEERVNEKI YEQLPVVVEE KNYEDALKEG AVALFTEKYG DKVRVVKIDD
670 680 690 700 710 720
YSMELCGGTH VKNTSEIGIF KIVSESAVGA GLRRIEALTG IEAIKYLNEQ KEILDRVSET
730 740 750 760 770 780
LKAQEKEVVS KIENLQQSLK DKEREIEGLK TKIASILAET LIDSAISVDG VKVIASRVED
790 800 810 820 830 840
YDMEALKTLG DILKDRLKSA AVILASSSKD KALFVGMATK DAVEKGVNMG AVIKETCSIA
850 860 870
EGNGGGRAEM AQGTGKNISK VKEALEKAIE IVKGQLKA