AiPD: Autoinhibited Protein Database

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

402-476 (Predicted disordered autoinhibitory region) PR

402-476 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8R5L3-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3388582600	3	D>G	No	EVA
rs3388584989	8	V>M	No	EVA
rs3388576972	42	I>T	No	EVA
rs3388579388	46	V>A	No	EVA
rs3388583379	97	I>F	No	EVA
rs3388583329	143	K>M	No	EVA
rs3388586949	170	M>T	No	EVA
rs3388581197	181	F>L	No	EVA
rs3388580835	248	V>M	No	EVA
rs3388579396	275	L>M	No	EVA
rs3388580801	284	P>A	No	EVA
rs3388574597	304	W>*	No	EVA
rs3388579366	334	K>N	No	EVA
rs3388582593	349	K>E	No	EVA
rs3388583571	438	S>P	No	EVA
rs3388578526	477	A>S	No	EVA
rs3388586953	487	C>Y	No	EVA
rs3388578502	521	V>M	No	EVA
rs3388578500	539	T>M	No	EVA
rs3388570125	553	L>M	No	EVA
rs3388583540	593	I>T	No	EVA
rs3388582552	636	D>N	No	EVA
rs3388576929	639	L>M	No	EVA
rs3388581213	675	D>N	No	EVA
rs3388583523	678	R>W	No	EVA
rs3388584985	706	L>F	No	EVA
rs3388580867	725	K>R	No	EVA
rs3388586961	726	H>Q	No	EVA
rs3388579413	791	L>M	No	EVA
rs3388579341	855	C>Y	No	EVA
rs3388574594	867	Y>H	No	EVA
rs3388582040	873	V>M	No	EVA
rs3388580826	883	S>T	No	EVA

Type	Name	Position	InterPro Accession
repeat	Clathrin, heavy chain/VPS, 7-fold repeat	573 - 750	IPR000547
domain	Citron homology (CNH) domain	10 - 300	IPR001180
domain	Vacuolar sorting protein 39/Transforming growth factor beta receptor-associated domain 1	460 - 562	IPR019452
domain	Vacuolar sorting protein 39/Transforming growth factor beta receptor-associated domain 2	772 - 879	IPR019453

		Description
EC Number
Subcellular Localization	Cytoplasm Lysosome membrane ; Peripheral membrane protein Late endosome membrane ; Peripheral membrane protein	Colocalizes with TGFBR1 and TGFBR2 in cytoplasmic vesicular structures and most prominently in cortical vesicles
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
HOPS complex	A multimeric protein complex that associates with the vacuolar membrane, late endosomal (multivesicular body) and lysosomal membranes. HOPS is a tethering complex involved in vesicle fusion.
late endosome	A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
late endosome membrane	The lipid bilayer surrounding a late endosome.
lysosomal HOPS complex	Any HOPS complex that is part of a lysosomal membrane.
lysosomal membrane	The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

Name	Definition
No GO annotations for molecular function

Name	Definition
autophagosome-lysosome fusion	The process in which autophagosomes, double-membraned vesicles containing cytoplasmic material, fuse with a vacuole (yeast) or lysosome (e.g. mammals and insects). In the case of yeast, inner membrane-bounded structures (autophagic bodies) appear in the vacuole. Fusion provides an acidic environment and digestive function to the interior of the autophagosome.
autophagy	The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation.
endocytic recycling	The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins.
endosomal vesicle fusion	The homotypic fusion of endocytic vesicles to form or add to an early endosome.
endosome to lysosome transport	The directed movement of substances from endosomes to lysosomes.
intracellular protein transport	The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
late endosome to lysosome transport	The directed movement of substances from late endosome to lysosome.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins