Q8R574

PR
Gene name
Prpsap2
Protein name
Phosphoribosyl pyrophosphate synthase-associated protein 2
Names
PRPP synthase-associated protein 2, 41 kDa phosphoribosypyrophosphate synthetase-associated protein, PAP41
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:212627
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

190-264 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8R574

Entry ID Method Resolution Chain Position Source
AF-Q8R574-F1 Predicted AlphaFoldDB

13 variants for Q8R574

Variant ID(s) Position Change Description Diseaes Association Provenance
rs225395865 5 A>T No EVA
rs262794866 21 V>G No EVA
rs248407142 36 K>R No EVA
rs3402200694 67 V>L No EVA
rs3389163425 107 V>L No EVA
rs3389140084 123 G>D No EVA
rs3389161649 126 V>I No EVA
rs3389138730 141 H>Y No EVA
rs3389177483 221 L>* No EVA
rs3389163263 263 R>G No EVA
rs3389151942 322 N>K No EVA
rs3389163226 339 V>L No EVA
rs3389163638 347 E>G No EVA

No associated diseases with Q8R574

2 regional properties for Q8R574

Type Name Position InterPro Accession
domain Phosphoribosyltransferase domain 165 - 323 IPR000836
domain Ribose-phosphate pyrophosphokinase, N-terminal domain 28 - 138 IPR029099

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
ribose phosphate diphosphokinase complex A protein complex having ribose phosphate diphosphokinase activity.

3 GO annotations of molecular function

Name Definition
identical protein binding Binding to an identical protein or proteins.
magnesium ion binding Binding to a magnesium (Mg) ion.
ribose phosphate diphosphokinase activity Catalysis of the reaction: D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + 2 H(+).

3 GO annotations of biological process

Name Definition
5-phosphoribose 1-diphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of 5-phosphoribose 1-diphosphate, also known as 5-phosphoribosyl-1-pyrophosphate.
bone development The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components.
purine nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O60256 PRPSAP2 Phosphoribosyl pyrophosphate synthase-associated protein 2 Homo sapiens (Human) PR
10 20 30 40 50 60
MFCVAPPELE TKMNITKGGL VLFSANSNSS CMELSKKIAE RLGVEMGKVQ VYQEPNRETR
70 80 90 100 110 120
VQIQESVRGK DVFIIQTISK DVNTTIMELL IMVYACKTSC AKSIIGVIPY FPYSKQCKMR
130 140 150 160 170 180
KRGSIVSKLL ASMMCKAGLT HLITMDLHQK EIQGFFNIPV DNLRASPFLL QYIQEEIPDY
190 200 210 220 230 240
RNAVIVAKSP ASAKRAQSFA ERLRLGIAVI HGEAQDAESD LVDGRHSPPM VRSVAAIHPS
250 260 270 280 290 300
LEIPMLIPKE KPPITVVGDV GGRIAIIVDD IIDDVDSFLA AAETLKERGA YKIFVMATHG
310 320 330 340 350 360
LLSSDAPRLI EESAIDEVVV TNTIPHEIQK LQCPKIKTVD ISMILSEAIR RIHNGESMSY
LFRNIGLDD