Q8R4E6
Gene name |
Purg |
Protein name |
Purine-rich element-binding protein gamma |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:75029 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8R4E6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8R4E6-F1 | Predicted | AlphaFoldDB |
3 variants for Q8R4E6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs33358695 | 222 | D>E | No | EVA | |
| rs223258974 | 251 | I>M | No | EVA | |
| rs3388982885 | 303 | I>V | No | EVA |
No associated diseases with Q8R4E6
No regional properties for Q8R4E6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q8R4E6 | |||
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA-binding transcription factor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. |
| purine-rich negative regulatory element binding | Binding to a 30-bp purine-rich negative regulatory element; the best characterized such element is found in the first intronic region of the rat cardiac alpha-myosin heavy chain gene, and contains two palindromic high-affinity Ets-binding sites (CTTCCCTGGAAG). The presence of this element restricts expression of the gene containing it to cardiac myocytes. |
| RNA polymerase II transcription regulatory region sequence-specific DNA binding | Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MERARRRGGG | GSGGGRGRGG | KNVGGPGLSK | SRLYPQAQHS | HYPHYSASAT | PNQSGGTSEI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QELASKRVDI | QKKRFYLDVK | QSSRGRFLKI | AEVWIGRGRQ | DNIRKSKLTL | SLSVAAELKD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| CLGDFIEHYA | HLGLKGHRQE | HGQSKEQVSR | RRQKHSAPSP | PVSVGSEEHP | HSVLKTDYIE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RDNRKYYLDL | KENQRGRFLR | IRQTMMRGTG | MIGYFGHSLG | QDQTIVLPAQ | GMIEFRDALV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QLIEDYGEGD | IEERRCGDDD | PLELPEGTSF | RVDNKRFYFD | VGSNKYGIFL | KVSEVRPPYR |
| 310 | 320 | 330 | 340 | ||
| NTITVPFKAW | TRFGENFIKY | EEEMRKICNS | HKEKRMDGRR | ASGEEQECLD |