AiPD: Autoinhibited Protein Database

Gene name	Ttc4
Protein name	Tetratricopeptide repeat protein 4
Names	TPR repeat protein 4
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:72354
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-94 (Predicted disordered autoinhibitory region) PR

1-94 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8R3H9-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs222342331	9	T>S	No	EVA
rs3388696904	28	G>S	No	EVA
rs3388697276	37	E>D	No	EVA
rs3388694021	38	E>D	No	EVA
rs3388693600	70	D>V	No	EVA
rs3394624449	95	Y>C	No	EVA
rs246926683	128	Y>F	No	EVA
rs3388694773	149	G>C	No	EVA
rs3388694773	149	G>R	No	EVA
rs28135153	172	N>S	No	EVA
rs3388697281	199	R>M	No	EVA
rs213831558	212	E>G	No	EVA
rs239714965	239	G>S	No	EVA
rs28135169	268	S>T	No	EVA
rs3388699312	311	E>G	No	EVA
rs3388691562	329	Y>N	No	EVA
rs3388686376	344	D>N	No	EVA
rs3388697252	347	L>Q	No	EVA
rs3388697222	355	R>M	No	EVA
rs28135194	357	C>S	No	EVA
rs215327794	358	V>M	No	EVA
rs3388678137	362	T>N	No	EVA
rs259801377	370	G>R	No	EVA

Type	Name	Position	InterPro Accession
repeat	Tetratricopeptide repeat	79 - 112	IPR019734-1
repeat	Tetratricopeptide repeat	117 - 150	IPR019734-2
repeat	Tetratricopeptide repeat	151 - 184	IPR019734-3
domain	Cns1/TTC4, wheel domain	272 - 355	IPR044059

		Description
EC Number
Subcellular Localization	Nucleus Nucleus, nucleoplasm Cytoplasm	Predominantly nuclear in the G1 and S phases of cell cycle and is evenly distributed between the nucleus and cytoplasm in the G2 phase (PubMed:19390865) MSL1 can promote its nuclear localization (PubMed:19390865, PubMed:24913909)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

Name	Definition
Hsp70 protein binding	Binding to a Hsp70 protein, heat shock proteins around 70kDa in size.
Hsp90 protein binding	Binding to Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size.

Name	Definition
defense response to virus	Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
innate immune response	Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
protein folding	The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins