Q8R326

PR
Gene name
Pspc1 (Psp1)
Protein name
Paraspeckle component 1
Names
Paraspeckle protein 1, mPSP1
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:66645
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

213-290 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8R326

Entry ID Method Resolution Chain Position Source
AF-Q8R326-F1 Predicted AlphaFoldDB

10 variants for Q8R326

Variant ID(s) Position Change Description Diseaes Association Provenance
rs228734679 29 S>N No EVA
rs3389333561 391 M>* No EVA
rs3389344374 439 P>S No EVA
rs3389255756 444 G>R No EVA
rs3389297025 445 P>Q No EVA
rs3389335003 459 N>D No EVA
rs3389335404 466 R>S No EVA
rs3389334922 486 E>D No EVA
rs3389332518 493 S>G No EVA
rs3389324125 516 G>C No EVA

No associated diseases with Q8R326

4 regional properties for Q8R326

Type Name Position InterPro Accession
domain RNA recognition motif domain 81 - 153 IPR000504-1
domain RNA recognition motif domain 155 - 236 IPR000504-2
domain NOPS 228 - 279 IPR012975
domain PSP1, RNA recognition motif 1 80 - 150 IPR034522

Functions

Description
EC Number
Subcellular Localization
  • Nucleus speckle
  • Nucleus, nucleolus
  • Nucleus matrix
  • Cytoplasm
  • In punctate subnuclear structures often located adjacent to splicing speckles, called paraspeckles
  • Colocalizes with NONO and SFPQ in paraspeckles and perinucleolar caps in an RNA-dependent manner
  • May cycle between paraspeckles and nucleolus
  • In telophase, when daughter nuclei form, localizes to perinucleolar caps
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
fibrillar center A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures.
nuclear matrix The dense fibrillar network lying on the inner side of the nuclear membrane.
nuclear speck A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
paraspeckles Discrete subnuclear bodies in the interchromatin nucleoplasmic space, often located adjacent to nuclear specks. 10-20 paraspeckles are typically found in human cell nuclei.

1 GO annotations of molecular function

Name Definition
RNA binding Binding to an RNA molecule or a portion thereof.

6 GO annotations of biological process

Name Definition
activation of innate immune response Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species.
innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
negative regulation of DNA-templated transcription Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
regulation of circadian rhythm Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
regulation of DNA-templated transcription Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
rhythmic process Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8WXF1 PSPC1 Paraspeckle component 1 Homo sapiens (Human) PR
Q4KLH4 Pspc1 Paraspeckle component 1 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MMLRGNLKQV RIEKNPARLR ALESAAGESE PVAAAAMALT LAGEQAPPPA PSEEHPDEEL
70 80 90 100 110 120
GFTIDIKSFL KPGEKTYTQR CRLFVGNLPT DITEEDFKRL FERYGEPSEV FINRDRGFGF
130 140 150 160 170 180
IRLESRTLAE IAKAELDGTI LKSRPLRIRF ATHGAALTVK NLSPVVSNEL LEQAFSQFGP
190 200 210 220 230 240
VEKAVVVVDD RGRATGKGFV EFAAKPPARK ALERCGDGAF LLTTTPRPVI VEPMEQFDDE
250 260 270 280 290 300
DGLPEKLMQK TQQYHKEREQ PPRFAQPGTF EFEYASRWKA LDEMEKQQRE QVDRNIREAK
310 320 330 340 350 360
EKLEAEMEAA RHEHQLMLMR QDLMRRQEEL RRLEELRNQE LQKRKQIQLR HEEEHRRREE
370 380 390 400 410 420
EMIRHREQEE LRRQQEGGFK PNYMENREQE MRMGDMGPRG AINMGDAFSP APAGTQGPPP
430 440 450 460 470 480
MMGMNMNNRG TIPGPPMGPG PAMGPEGAAN MGTPMIPDNG AVHNDRFPQG PPSQMGSPMG
490 500 510 520
NRTGSETPQA PMSGVGPVSG GPGGFGRGSQ GGNFEGPNKR RRY