Q8R0H9

EV
Gene name
Gga1
Protein name
ADP-ribosylation factor-binding protein GGA1
Names
Gamma-adaptin-related protein 1, Golgi-localized, gamma ear-containing, ARF-binding protein 1
Species
Homo sapiens (Human)
KEGG Pathway
mmu:106039
EC number
2.3.2.27: Aminoacyltransferases
Protein Class
TNF RECEPTOR ASSOCIATED FACTOR (PTHR10131)

Descriptions

The Tumor Necrosis Factor (TNF) Receptor Associated Factor (TRAF) class of intracellular signal transducers is responsible for mediating many of the activation events initiated by TNF receptor (TNFR) and Toll-like/Interleukin-1, 17 and 18 receptor (TIR) families. ​​These receptors can, both directly and indirectly, activate TRAF6 via specific binding of proteins containing TRAF Interacting Motif (TIM) peptides to a groove on the carboxyl-terminal MATH domain.
TRAF6 is autoinhibited by an intramolecular interaction between the RING-Zinc (RZ) region and MATH domain. The interaction renders TRAF6 inactive and structurally closed, as well as incapable of auto-ubiquitination. RING-Zinc fingers region and the MATH domain are targets for ubiquitination. TRAF autoubiquitination in trans is a means of sustaining an open conformation active in downstream signaling.

Autoinhibitory domains (AIDs)

354-361 (Autoinhibitory site in hinge region) SS

Target domain

8-147 (VHS domain)

Relief mechanism

PTM

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8R0H9

Entry ID Method Resolution Chain Position Source
AF-Q8R0H9-F1 Predicted AlphaFoldDB

3 variants for Q8R0H9

Variant ID(s) Position Change Description Diseaes Association Provenance
rs221719202 76 S>N No Ensembl
rs235343013 344 S>N No Ensembl
rs228963591 400 A>V No Ensembl

No associated diseases with Q8R0H9

No regional properties for Q8R0H9

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q8R0H9

Functions

Description
EC Number 2.3.2.27 Aminoacyltransferases
Subcellular Localization
  • Cytoplasm
  • Cytoplasm, cell cortex
  • Nucleus
  • Lipid droplet
  • Found in the nuclei of some aggressive B-cell lymphoma cell lines as well as in the nuclei of both resting and activated T- and B-lymphocytes
  • Found in punctate nuclear body protein complexes
  • Ubiquitination may occur in the cytoplasm and sumoylation in the nucleus
  • RSAD2/viperin recruits it to the lipid droplet (By similarity)
PANTHER Family PTHR10131 TNF RECEPTOR ASSOCIATED FACTOR
PANTHER Subfamily PTHR10131:SF131 TNF RECEPTOR-ASSOCIATED FACTOR 6
PANTHER Protein Class scaffold/adaptor protein
PANTHER Pathway Category CCKR signaling map
TRAF6
p38 MAPK pathway
TRAF6
Toll receptor signaling pathway
TRAF6

7 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
early endosome A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
early endosome membrane The lipid bilayer surrounding an early endosome.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.

3 GO annotations of molecular function

Name Definition
phosphatidylinositol binding Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives.
small GTPase binding Binding to a small monomeric GTPase.
ubiquitin binding Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation.

9 GO annotations of biological process

Name Definition
Golgi to plasma membrane protein transport The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane.
Golgi to plasma membrane transport The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis.
intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
positive regulation of protein catabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
protein localization Any process in which a protein is transported to, or maintained in, a specific location.
protein localization to cell surface A process in which a protein is transported to, or maintained in, a location within the external part of the cell wall and/or plasma membrane.
protein localization to ciliary membrane A process in which a protein is transported to, or maintained in, a location within a ciliary membrane.
retrograde transport, endosome to Golgi The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport.
toxin transport The directed movement of a toxin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9UJY4 GGA2 ADP-ribosylation factor-binding protein GGA2 Homo sapiens (Human) SS
Q9UJY5 GGA1 ADP-ribosylation factor-binding protein GGA1 Homo sapiens (Human) EV
Q9NZ52 GGA3 ADP-ribosylation factor-binding protein GGA3 Homo sapiens (Human) EV
Q8BMI3 Gga3 ADP-ribosylation factor-binding protein GGA3 Mus musculus (Mouse) SS
Q6P5E6 Gga2 ADP-ribosylation factor-binding protein GGA2 Mus musculus (Mouse) SS
10 20 30 40 50 60
MSLLNCENSC GSSQSESDCC VAMASSCSAV TKDDSVGGTA STGNLSSSFM EEIQGYDVEF
70 80 90 100 110 120
DPPLESKYEC PICLMALREA VQTPCGHRFC KACIIKSIRD AGHKCPVDNE ILLENQLFPD
130 140 150 160 170 180
NFAKREILSL MVKCPNEGCL HKMELRHLED HQAHCEFALM DCPQCQRPFQ KFHINIHILK
190 200 210 220 230 240
DCPRRQVSCD NCAASMAFED KEIHDQNCPL ANVICEYCNT ILIREQMPNH YDLDCPTAPI
250 260 270 280 290 300
PCTFSTFGCH EKMQRNHLAR HLQENTQSHM RMLAQAVHSL SVIPDSGYIS EVRNFQETIH
310 320 330 340 350 360
QLEGRLVRQD HQIRELTAKM ETQSMYVSEL KRTIRTLEDK VAEIEAQQCN GIYIWKIGNF
370 380 390 400 410 420
GMHLKCQEEE KPVVIHSPGF YTGKPGYKLC MRLHLQLPTA QRCANYISLF VHTMQGEYDS
430 440 450 460 470 480
HLPWPFQGTI RLTILDQSEA PVRQNHEEIM DAKPELLAFQ RPTIPRNPKG FGYVTFMHLE
490 500 510 520
ALRQRTFIKD DTLLVRCEVS TRFDMGSLRR EGFQPRSTDA GV