Q8QZY1
PR
Gene name |
Eif3l (Eif3eip, Eif3s6ip, Paf67) |
Protein name |
Eukaryotic translation initiation factor 3 subunit L |
Names |
eIF3l, 66 kDa tyrosine-rich heat shock protein, 67 kDa polymerase-associated factor, Eukaryotic translation initiation factor 3 subunit 6-interacting protein, Eukaryotic translation initiation factor 3 subunit E-interacting protein, HSP-66Y, PAF67 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:223691 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8QZY1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8QZY1-F1 | Predicted | AlphaFoldDB |
34 variants for Q8QZY1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389374428 | 3 | Y>* | No | EVA | |
| rs3406188471 | 31 | K>R | No | EVA | |
| rs3406393039 | 32 | Q>H | No | EVA | |
| rs3389352862 | 57 | Q>H | No | EVA | |
| rs3389374405 | 109 | N>I | No | EVA | |
| rs3389374564 | 122 | V>D | No | EVA | |
| rs3389388678 | 127 | V>I | No | EVA | |
| rs3389369613 | 173 | P>H | No | EVA | |
| rs218487852 | 210 | G>E | No | EVA | |
| rs245461460 | 212 | M>I | No | EVA | |
| rs31583179 | 221 | V>I | No | EVA | |
| rs3389374553 | 258 | G>R | No | EVA | |
| rs3389374480 | 259 | E>K | No | EVA | |
| rs3389366506 | 269 | L>F | No | EVA | |
| rs3389366505 | 270 | G>D | No | EVA | |
| rs3389369628 | 317 | Y>F | No | EVA | |
| rs3389382929 | 326 | M>K | No | EVA | |
| rs3389341803 | 354 | T>I | No | EVA | |
| rs3389341822 | 364 | N>D | No | EVA | |
| rs3389341856 | 380 | M>I | No | EVA | |
| rs3389374522 | 385 | S>N | No | EVA | |
| rs3389369642 | 386 | I>L | No | EVA | |
| rs3389366468 | 389 | Q>* | No | EVA | |
| rs3406021139 | 407 | Q>H | No | EVA | |
| rs3389382973 | 423 | P>H | No | EVA | |
| rs3389379146 | 425 | V>M | No | EVA | |
| rs3389372827 | 433 | P>L | No | EVA | |
| rs3405775196 | 438 | E>Q | No | EVA | |
| rs3389377374 | 493 | F>L | No | EVA | |
| rs3389335549 | 531 | A>T | No | EVA | |
| rs3389341798 | 532 | D>Y | No | EVA | |
| rs3389374454 | 538 | R>C | No | EVA | |
| rs3406276847 | 545 | R>* | No | EVA | |
| rs13465611 | 548 | H>L | No | EVA |
No associated diseases with Q8QZY1
7 regional properties for Q8QZY1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | FERM domain | 17 - 298 | IPR000299 |
| domain | FERM adjacent | 308 - 354 | IPR014847 |
| domain | FERM, N-terminal | 21 - 83 | IPR018979 |
| domain | FERM, C-terminal PH-like domain | 214 - 302 | IPR018980 |
| conserved_site | FERM conserved site | 71 - 100 | IPR019747 |
| domain | FERM central domain | 103 - 210 | IPR019748 |
| domain | Band 4.1 domain | 13 - 210 | IPR019749 |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| eukaryotic 43S preinitiation complex | A protein complex composed of the 40S ribosomal subunit plus eIF1A, eIF3, and eIF2-GTP-bound methionyl-initiator methionine tRNA. |
| eukaryotic 48S preinitiation complex | A protein complex composed of the small ribosomal subunit, eIF3, eIF1A, methionyl-initiatior methionine and a capped mRNA. The complex is initially positioned at the 5'-end of the capped mRNA. |
| eukaryotic translation initiation factor 3 complex | A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs. |
| fibrillar center | A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| translation initiation factor activity | Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| formation of cytoplasmic translation initiation complex | Joining of the large subunit, with release of IF2/eIF2 and IF3/eIF3. This leaves the functional ribosome at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site. |
| translational initiation | The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA. |
| viral translational termination-reinitiation | A process which occurs as part of viral mRNA translation which allows expression of a downstream open reading frame (ORF) in a dicistronic mRNA. In this process, ribosomes translate the upstream ORF but following termination, a proportion of 40S subunits remain tethered to the mRNA and go on to re-initiate translation at the start codon of the downstream ORF. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3ZCK1 | EIF3L | Eukaryotic translation initiation factor 3 subunit L | Bos taurus (Bovine) | PR |
| Q5F428 | EIF3L | Eukaryotic translation initiation factor 3 subunit L | Gallus gallus (Chicken) | PR |
| A5A6M4 | EIF3L | Eukaryotic translation initiation factor 3 subunit L | Pan troglodytes (Chimpanzee) | PR |
| Q9Y262 | EIF3L | Eukaryotic translation initiation factor 3 subunit L | Homo sapiens (Human) | PR |
| Q6P878 | eif3l | Eukaryotic translation initiation factor 3 subunit L | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q7T2A5 | eif3l | Eukaryotic translation initiation factor 3 subunit L | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSYPADDYES | EAAYDPYAYP | GDYDMHTGDP | KQDLAYERQY | EQQTYQVIPE | VIKNFIQYFH |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KTVSDLIDQK | VYELQASRVS | SDVIDQKVYE | IQDIYENSWT | KLTERFFKNT | PWPEAEAIAP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QVGNDAVFLI | LYKELYYRHI | YAKVSGGPSL | EQRFESYYNY | CNLFNYILNA | DGPAPLELPN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QWLWDIIDEF | IYQFQSFSQY | RCKTAKKSEG | EMDFLRSNPK | VWNVHSVLNV | LHSLVDKSNI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NRQLEVYTSG | GDPESVAGEY | GRHSLYKMLG | YFSLVGLLRL | HSLLGDYYQA | IKVLENIELN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KKSMYSRVPE | CQVTTYYYVG | FAYLMMRRYQ | DAIRVFANIL | LYIQRTKSMF | QRTTYKYEMI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NKQNEQMHAL | LAIALTMYPM | RIDESIHLQL | REKYGDKMLR | MQKGDPQVYE | ELFSYACPKF |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LSPVVPNYDN | VHPNYHKEPF | LQQLKVFSDE | VQQQAQLSTI | RSFLKLYTTM | PVAKLAGFLD |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LTEQEFRIQL | LVFKHKMKNL | VWTSGISALD | GEFQSASEVD | FYIDKDMIHI | ADTKVARRYG |
| 550 | 560 | ||||
| DFFIRQIHKF | EELNRTLKKM | GQRP |