Q8Q0M2
Gene name |
truD |
Protein name |
Probable tRNA pseudouridine synthase D |
Names |
tRNA pseudouridine(13) synthase, tRNA pseudouridylate synthase D, tRNA-uridine isomerase D |
Species |
Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia) |
KEGG Pathway |
mma:MM_0114 |
EC number |
5.4.99.27: Transferring other groups |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for Q8Q0M2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1Z2Z | X-ray | 260 A | A/B | 1-438 | PDB |
| AF-Q8Q0M2-F1 | Predicted | AlphaFoldDB |
No variants for Q8Q0M2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q8Q0M2 | |||||
No associated diseases with Q8Q0M2
3 regional properties for Q8Q0M2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Translation elongation factor EFTs/EF1B, dimerisation | 29 - 199 | IPR014039 |
| conserved_site | Translation elongation factor Ts, conserved site | 12 - 27 | IPR018101-1 |
| conserved_site | Translation elongation factor Ts, conserved site | 77 - 87 | IPR018101-2 |
Functions
| Description | ||
|---|---|---|
| EC Number | 5.4.99.27 | Transferring other groups |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| tRNA pseudouridine synthase activity | Catalysis of the reaction: tRNA uridine = tRNA pseudouridine. Conversion of uridine in a tRNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| tRNA pseudouridine synthesis | The intramolecular conversion of uridine to pseudouridine in a tRNA molecule. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEVPEIEKQI | GINLYSTDTT | GLGGQLRQEI | EDFIVKEITN | REEGEEGKYL | IVELTKRDWD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| THHLTRTLSR | ILQVSQKRIS | VAGTKDKRAL | TTQKISIFDT | DASEIEKIHL | KDIELKVLGR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SRKSVELGDL | WGNDFRITVR | NIENSPEETE | ALLKKTTDEI | LAQGGVPNFF | GIQRFGSVRP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VTHLVGKAIV | EGNFEKAALL | YIAEPFPEEP | EETKNARQFV | KDTLDFKEGL | KTYPLRLGHE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RAMMNHLIAN | PEDYSGSFRV | LPQNLYRMFV | HGYQSYIYNI | ILCRRIEAGI | PLNRAVEGDI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VCFRNEVGLP | DSSKTEKVTS | ETVNAMNRLL | KLGRAFITAP | LPGYNTEFAS | GIPGEIENGV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LKELGVSLEG | FNIEKFPEMS | SKGTRREVLL | EVKPKFEAGE | DELNPGKSKA | VLEFMLPKGS |
| 430 | |||||
| YATTVLREYM | KVNPLQMS |