Q8PZR8
Gene name |
hisD |
Protein name |
Histidinol dehydrogenase |
Names |
HDH |
Species |
Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia) |
KEGG Pathway |
mma:MM_0424 |
EC number |
1.1.1.23: With NAD(+) or NADP(+) as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8PZR8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8PZR8-F1 | Predicted | AlphaFoldDB |
No variants for Q8PZR8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q8PZR8 | |||||
No associated diseases with Q8PZR8
1 regional properties for Q8PZR8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Histidinol dehydrogenase, conserved site | 230 - 262 | IPR001692 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.1.1.23 | With NAD(+) or NADP(+) as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| histidinol dehydrogenase activity | Catalysis of the reaction: L-histidinol + NAD+ = L-histidine + NADH + H+. |
| NAD binding | Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. |
| zinc ion binding | Binding to a zinc ion (Zn). |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| histidine biosynthetic process | The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MIIMLFKKLS | DVSEAEMQRL | ISRGSGLADV | GDTVSAVLSD | VRMKGDAALR | EYTKKFDKVE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LANFEVSEEE | FEKALSEIGS | ELLGHLRIAA | ENIRAFHRAQ | MPETTWFMEL | QPGVVLGQKA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TPLESVGAYA | PGGRASYPST | VLMTVIPARV | AGVEQVIVCT | PPRADGSVHP | LTLAAAKVAG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ADKVFKLGGV | QAIGAMAYGT | ETVPRVDKIV | GPGNVFVTSA | KMQVRDIAEI | DFPAGPSEVL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IIADESADAA | MAASDIIAQA | EHDPNAVSVL | VTTSETLAEE | VEQEVLAQAE | STARSEIVKI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SLENAAVLIA | DSLDQCIDFS | NKFAPEHLEI | MVEDSDFVLD | RIKNAGSIFI | GNYAPVPVGD |
| 370 | 380 | 390 | 400 | 410 | 420 |
| YASGTNHVLP | TAGYAKIYSG | LNINHFLKYS | SIQKISKSGL | ESLKETVIAL | AEEEGLKAHA |
| 430 | |||||
| DSIRARFGYR | PSK |