Q8PXE1

PR
Gene name
fae-hps
Protein name
Bifunctional enzyme Fae/Hps
Names
Species
Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)
KEGG Pathway
mma:MM_1279
EC number
4.1.2.43: Aldehyde-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

59-128 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8PXE1

Entry ID Method Resolution Chain Position Source
AF-Q8PXE1-F1 Predicted AlphaFoldDB

No variants for Q8PXE1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8PXE1

No associated diseases with Q8PXE1

No regional properties for Q8PXE1

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q8PXE1

Functions

Description
EC Number 4.1.2.43 Aldehyde-lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
carbon-nitrogen lyase activity Catalysis of the release of ammonia or one of its derivatives, with the formation of a double bond or ring. Enzymes with this activity may catalyze the actual elimination of the ammonia, amine or amide, e.g. CH-CH(-NH-R) = C=CH- + NH2-R. Others, however, catalyze elimination of another component, e.g. water, which is followed by spontaneous reactions that lead to breakage of the C-N bond, e.g. L-serine ammonia-lyase (EC:4.3.1.17), so that the overall reaction is C(-OH)-CH(-NH2) = CH2-CO- + NH3, i.e. an elimination with rearrangement. The sub-subclasses of EC:4.3 are the ammonia-lyases (EC:4.3.1), lyases acting on amides, amidines, etc. (EC:4.3.2), the amine-lyases (EC:4.3.3), and other carbon-nitrogen lyases (EC:4.3.99).
hexulose-6-phosphate synthase activity Catalysis of the reaction: D-ribulose 5-phosphate + formaldehyde = D-arabino-3-hexulose 6-phosphate.
hydro-lyase activity Catalysis of the cleavage of a carbon-oxygen bond by elimination of water.
orotidine-5'-phosphate decarboxylase activity Catalysis of the reaction: H(+) + orotidine 5'-phosphate = CO(2) + UMP.

2 GO annotations of biological process

Name Definition
'de novo' pyrimidine nucleobase biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors.
carbohydrate biosynthetic process The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MFQIGEALMG QGSELAHVDL MIGDKGGPVG QAFANGLTQL SAGHTPLLSV IRPNLPPKPS
70 80 90 100 110 120
TLIIPKVTVK NMDQAARIFG PAQSAVAKAV ADSVEEGVIP KDQVEDLVIV ASVFIHPEAQ
130 140 150 160 170 180
DYNKIYRYNY GATKLAIKRA LEGFPDIDTV LEESNKSTHA IMGFKVTRLW DPPYLQIAFD
190 200 210 220 230 240
NPNLEFVLSA ISEIPKSDHV IIEAGTPLIK RYGTDVISKI RQVRPDAFIV ADLKTLDTGN
250 260 270 280 290 300
LEARMVADAA GDAIVVSALA PISTIDKLIE EAHKTGIYAV MDTLNQQDPI SVLKQLKVMP
310 320 330 340 350 360
DVIELHRGID IEGTEHAWGN IGEIKKIAPK ALVAVAGGVR LDKVPVALSQ GADILVVGRA
370 380 390
ITNAKDVREM AEQFINSLNK PEIDQFRVMT DF