Q8PX25

PR
Gene name
pcn
Protein name
DNA polymerase sliding clamp
Names
Proliferating cell nuclear antigen homolog, PCNA
Species
Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)
KEGG Pathway
mma:MM_1397
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

144-213 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8PX25

Entry ID Method Resolution Chain Position Source
AF-Q8PX25-F1 Predicted AlphaFoldDB

No variants for Q8PX25

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8PX25

No associated diseases with Q8PX25

3 regional properties for Q8PX25

Type Name Position InterPro Accession
domain Proliferating cell nuclear antigen, PCNA, N-terminal 2 - 97 IPR022648
domain Proliferating cell nuclear antigen, PCNA, C-terminal 122 - 240 IPR022649
conserved_site Proliferating cell nuclear antigen, PCNA, conserved site 33 - 56 IPR022659

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA polymerase processivity factor activity An enzyme regulator activity that increases the processivity of polymerization by DNA polymerase, by allowing the polymerase to move rapidly along DNA while remaining topologically bound to it.

2 GO annotations of biological process

Name Definition
DNA replication The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
regulation of DNA replication Any process that modulates the frequency, rate or extent of DNA replication.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MFKAAINAEL LKDAIASLAV IVDEVRFKIK PEGISVKAVD PANVAMGIFE LGSSAFEEYS
70 80 90 100 110 120
ADECEIGIDL NKITDLLGIA DRNDTVRMEL DEGSNKLLID VGGLSYTLSL LDPSTIRAEP
130 140 150 160 170 180
RVPQLELPAK VVLNGADLRR AVKAAEKISD HMLMGVSGDT FYMEAKGDTD QVRLEMGRDQ
190 200 210 220 230 240
LIDLKAGEAC SLFSLDYLTD IVKPTNKVNE VTLSLGRDFP ILIDFEIANG AGRISYLLAP
RIESD