Q8PWU0

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)
KEGG Pathway
mma:MM_1486
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

393-535 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8PWU0

Entry ID Method Resolution Chain Position Source
AF-Q8PWU0-F1 Predicted AlphaFoldDB

No variants for Q8PWU0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8PWU0

No associated diseases with Q8PWU0

4 regional properties for Q8PWU0

Type Name Position InterPro Accession
domain DHHA1 domain 736 - 871 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 656 - 699 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 8 - 559 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 4 - 712 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

5 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLEDEYQLDF FKNNGFVRKQ CQKCGTFFWT RDPERNTCGD APCDPYSFIG SPVFSREFNI
70 80 90 100 110 120
SEMREYYLSF FEARGHTRIN RYPVVARWRD DIYLTIASIA DFQPFVTSGQ VPPPANPLTI
130 140 150 160 170 180
SQPCIRLNDL DSVGRSGRHL TNFEMMAHHA FNRRDNEIYW KEHTLELCDE LLNSLKVNPL
190 200 210 220 230 240
AVTYKEEPWA GGGNAGPCVE VIVHGLELAT LVFMDLKTDK KGDIEIKGET YSKMDNYIVD
250 260 270 280 290 300
TGYGLERFVW ASRGSPTIYD ALFPGIVNEL MGLAGIEHEL NDSEYANILA QNARLAGFMD
310 320 330 340 350 360
VSEKANLMEL RKKVASSIGM TVDKLSAIME PVEKVYAITD HTRCLTFMLG DGIIPSNVKA
370 380 390 400 410 420
GYLARLVLRR TLRMMKDLDI RIPLSEIVDM HIKNMPEYPG FRENFPVIQD ILESEEEKFN
430 440 450 460 470 480
TTMERGRRII QKSASHFKKT GEKIPLSQLT ELYDSHGIPP EMAKEVAAEI GVGVEFPDNF
490 500 510 520 530 540
YSIIGELHNK AEEKEEEVNP YAERLKHLPK TKRRFYDEPT RLEFEAVVLD VFDNHVVLDN
550 560 570 580 590 600
TFFYAEGGGQ PADIGTIVAE DTVYRVVDVQ VYEGVILHTI ENPGKELAIT KGELITGKVD
610 620 630 640 650 660
EKRRMTLARH HTATHIVNDA ARKVLGKHIW QAGAQKFEDH SRLDLSHYKH ISPEEIRQIE
670 680 690 700 710 720
LLANRTVMEN KRVVTEWMPR TEAEQVYGFG LYQGGVPPGE KIRIVKVGDD VEACGGTHCT
730 740 750 760 770 780
STGIIGPIKI LKTERIQDGV ERIEFAAGTA AVRAMQKLES LLVDSSKTLS VPPEHLPVSV
790 800 810 820 830 840
DRFFGEWKDL KKENERLKEE LARSRVYRML GDASEVSGLK VITEQVSGAD SLELQKIATE
850 860 870 880 890 900
LLKTENVVAL LASDFEGVKI VASAGEKAMK CGVNAGNLVR EMSKIVGGGG GGKPALAMGG
910 920
GTDPTRIQDA LTRGLELVKT AACKEA