Q8P9X0
Gene name |
alaS |
Protein name |
Alanine--tRNA ligase |
Names |
Alanyl-tRNA synthetase, AlaRS |
Species |
Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25) |
KEGG Pathway |
xcc:XCC1724 |
EC number |
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8P9X0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8P9X0-F1 | Predicted | AlphaFoldDB |
No variants for Q8P9X0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q8P9X0 | |||||
No associated diseases with Q8P9X0
1 regional properties for Q8P9X0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Amidohydrolase-related | 49 - 427 | IPR006680 |
Functions
| Description | ||
|---|---|---|
| EC Number | 6.1.1.7 | Ligases forming aminoacyl-tRNA and related compounds |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| alanine-tRNA ligase activity | Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala). |
| amino acid binding | Binding to an amino acid, organic acids containing one or more amino substituents. |
| aminoacyl-tRNA editing activity | The hydrolysis of an incorrectly aminoacylated tRNA. |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| tRNA binding | Binding to a transfer RNA. |
| zinc ion binding | Binding to a zinc ion (Zn). |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| alanyl-tRNA aminoacylation | The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA. |
| negative regulation of DNA-templated transcription | Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. |
| tRNA modification | The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNAPAKFSTS | QIRSDFLAFF | EGKGHTIVPS | APLVPGNDPT | LLFTNSGMVQ | FKDVFLGAEK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RSYVRAADVQ | RCLRAGGKHN | DLDSVGYTAR | HHTFFEMLGN | WSFGDYFKKD | AIAWAWELLT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QVWKLPADRL | LVTVYHTDEE | AFELWRDMIG | IPESRIVRIG | DNKGAPYASD | NFWQMADTGP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| CGPCTEIFFD | HGDHIAGGPP | GSPDEDGDRF | IEIWNLVFMQ | FDRQPDGTLV | ALPAPCVDTG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| MGLERLAAIL | QHVHTNYEID | VFQALIGKAS | ALTGIADLEN | KSLRVIADHI | RACSFLIVDG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VLPSNEGRGY | VLRRIIRRAL | RHGWMLGVRQ | LFFSKMVPTL | VELMGEAYPE | LVVAQETVAR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ALLAEEERFA | ETLDAGMKIF | DDVASRSQEI | IPGADAFRLY | DTYGFPVDLT | ADIARERGMR |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VDMEGFEFAM | ERQRETARAA | GKFGGGVALP | ADLVATMAPT | VFLGYEAQDA | DALKVVALLK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| QGRPVDRAEA | GDEVIVFTDR | TPFYAESGGQ | VGDSGQLSGT | DVSIEVADTQ | KFAGQFHGHV |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GRIAEGALKL | GDVLSGGIDV | QRRGKTILNH | SATHLLHAAL | REVLGTHVQQ | KGSLVAPDRL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| RFDFSHFQPI | TAEELAVIER | KVNAEVRTNH | SVEVHNMAMQ | EALDFGAMAL | FGEKYGERVR |
| 670 | 680 | 690 | 700 | 710 | 720 |
| VLKMGGYSTE | LCGGTHVSRT | GDIGLFKITS | EGGVSSGVRR | IEAVTGQGAL | DYVAEEERRL |
| 730 | 740 | 750 | 760 | 770 | 780 |
| GEAANLLGGN | STEIVDKVRA | LTDRQKRLER | ELESLKAKLA | SGATADLGAS | AVDVAGVKVI |
| 790 | 800 | 810 | 820 | 830 | 840 |
| AVRLEGFDAK | ALREAMDRLK | QQLGDSVIVL | AGAAGGKVAL | VAGVNGSPTG | KVKAGELLGH |
| 850 | 860 | 870 | 880 | ||
| IASQIGGKGG | GRPDLAQGGG | EDGPALATAL | QGVPSWVKQH | LG |